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Literature DB >> 248271

Mechanism of penicillin-erythromycin synergy on antibiotic-resistant Staphylococcus aureus.

Abstract

Clinically isolated strains of Staphylococcus aureus that are inducibly resistant to both erythromycin and penicillin were susceptible to a combination of the two antibiotics. The synergistic effect of the combination results from an inhibition of penicillinase induction by erythromycin, sparing penicillin and allowing this drug to inhibit growth. When resistance to erythromycin is constitutive rather than inducible, the combination is no longer synergistic.

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Year: 1978 PMID： 248271 PMCID： PMC352343 DOI： 10.1128/AAC.13.5.849

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Erythrocillin: a new approach to the problem of antibiotic-resistant staphylococci.

Authors: W E HERRELL; A BALOWS; J BECKER
Journal: Antibiotic Med Clin Ther (New York) Date: 1960-10

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Authors: C J PERRET
Journal: Nature Date: 1954-11-27 Impact factor: 49.962

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Authors: P M WATERWORTH
Journal: Clin Med (Northfield) Date: 1963-05

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Authors: A MANTEN; M J WISSE
Journal: Nature Date: 1961-11-18 Impact factor: 49.962

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Authors: R J Duma; L J Kinz
Journal: Appl Microbiol Date: 1968-08

6. Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase.

Authors: J Michel; J Jacobs; T Sacks
Journal: Chemotherapy Date: 1977 Impact factor: 2.544

7. Mechanis of chlorampenicol-cephalordine synergism on Enerobacteiaeae.

Authors: J Michel; H Bornstein; R Luboshitzky; T Sacks
Journal: Antimicrob Agents Chemother Date: 1975-06 Impact factor: 5.191

8. Preferential inhibition of penicillinase induction by oxytetracycline and its effect on the penicillin susceptibility of staphylococci.

Authors: T M Michael; J G Michael; B F Massell
Journal: J Bacteriol Date: 1967-06 Impact factor: 3.490

9. Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus.

Authors: C J Lai; B Weisblum
Journal: Proc Natl Acad Sci U S A Date: 1971-04 Impact factor: 11.205

10. Macrolide resistance in Staphylococcus aureus: induction of macrolide-resistant protein synthesis.

Authors: N E Allen
Journal: Antimicrob Agents Chemother Date: 1977-04 Impact factor: 5.191

5 in total

1. Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus.

Authors: J Michel; P Stessman; J Stessman
Journal: Antimicrob Agents Chemother Date: 1980-01 Impact factor: 5.191

2. In vitro antagonism by erythromycin of the bactericidal action of antimicrobial agents against common respiratory pathogens.

Authors: J R Cohn; D L Jungkind; J S Baker
Journal: Antimicrob Agents Chemother Date: 1980-12 Impact factor: 5.191

Review 3. An alternate pathophysiologic paradigm of sepsis and septic shock: implications for optimizing antimicrobial therapy.

Authors: Anand Kumar
Journal: Virulence Date: 2013-11-01 Impact factor: 5.882

4. Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats.

Authors: Zubin Zhou; Chenhao Pan; Ye Lu; Youshui Gao; Wei Liu; Peipei Yin; Xiaowei Yu
Journal: Front Cell Infect Microbiol Date: 2017-08-24 Impact factor: 5.293

Review 5. Multitarget Approaches against Multiresistant Superbugs.

Authors: Declan Alan Gray; Michaela Wenzel
Journal: ACS Infect Dis Date: 2020-03-19 Impact factor: 5.084

5 in total