| Literature DB >> 832037 |
L M Wing, J L Reid, D S Davies, H J Dargie, C T Dollery.
Abstract
Clonidine failed to reduce the blood pressures of two patients with essential hypertension. On was given 5-4 mg/day and the other 6 mg/day, and their respective peak plasma clonidine concentrations were 26-2 ng/ml and 14-4 ng/ml. Several months after the end of clonidine treatment a single oral dose of 0-3 mg of clonidine produced maximum falls in blood pressure of 30/22 mm Hg and 88/41 mm Hg with peak plasma clonidine concentrations of 1-4 ng/ml and 0-9 ng/ml. Resistance to the hypotensive effect of high doses of clonidine may be due to stimulation of peripheral alpha-adrenoceptors causing vasoconstriction, which maintains a raised blood pressure.Entities:
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Year: 1977 PMID： 832037 PMCID： PMC1603915 DOI： 10.1136/bmj.1.6054.136
Source DB: PubMed Journal: Br Med J ISSN： 0007-1447