Literature DB >> 8318404

TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.

A Avery1, C Paraskeva, P Hall, K C Flanders, M Sporn, M Moorghen.   

Abstract

Samples of colorectal carcinoma, adenoma and normal colorectal mucosa were examined for the expression of TGF-beta by immunohistochemistry. Immunoreactivity for TGF-beta was present in 52 out of a total of 58 samples of normal mucosa examined. In adenomas and carcinomas TGF-beta expression was observed in eight out of ten and 46 out of 48 samples respectively and was largely restricted to epithelial cells. In normal mucosa differential expression of TGF-beta was present within epithelial cells, those in the upper parts of the crypts showing enhanced immunoreactivity compared to cells in the proliferative compartment. This pattern of differential staining is consistent with TGF-beta having an important role in the control of growth and differentiation in colonic mucosa.

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Year:  1993        PMID： 8318404      PMCID： PMC1968322          DOI： 10.1038/bjc.1993.301

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  8 in total

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Authors:  A M Manning; A C Williams; S M Game; C Paraskeva
Journal:  Oncogene       Date:  1991-08       Impact factor: 9.867

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Journal:  J Biol Chem       Date:  1988-06-05       Impact factor: 5.157

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Review 6.  Transforming growth factor-beta: possible roles in carcinogenesis.

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Journal:  Br J Cancer       Date:  1988-06       Impact factor: 7.640

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8.  Complex regulation of TGF beta expression by retinoic acid in the vitamin A-deficient rat.

Authors:  A B Glick; B K McCune; N Abdulkarem; K C Flanders; J A Lumadue; J M Smith; M B Sporn
Journal:  Development       Date:  1991-04       Impact factor: 6.868
  8 in total
  21 in total

1.  TGF-beta signaling in colon cancer cells.

Authors:  Fazhi Li; Yanna Cao; Courtney M Townsend; Tien C Ko
Journal:  World J Surg       Date:  2005-03       Impact factor: 3.352

2.  Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice.

Authors:  Manoj K Pandey; Guangming Liu; Timothy K Cooper; Kathleen M Mulder
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3.  Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors.

Authors:  C S Potten; G Owen; D Hewitt; C A Chadwick; H Hendry; B I Lord; L B Woolford
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Authors:  S M Todryk; H Chong; R G Vile; H Pandha; N R Lemoine
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Authors:  C Booth; G S Evans; C S Potten
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-03       Impact factor: 2.416

6.  Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.

Authors:  Mary F Walsh; Dinakar R Ampasala; James Hatfield; Richard Vander Heide; Silke Suer; Arun K Rishi; Marc D Basson
Journal:  Am J Pathol       Date:  2008-06-26       Impact factor: 4.307

7.  Transforming growth factor beta 1 and metalloproteinase-9 overexpression in colorectal cancer (CC) and adenoma.

Authors:  Piotr Daniel; Malgorzata Wagrowska-Danilewicz; Marian Danilewicz; Olga Stasikowska; Ewa Malecka-Panas
Journal:  Int J Colorectal Dis       Date:  2007-03-30       Impact factor: 2.571

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Authors:  Ruth Y Lan; Ian R Mackay; M Eric Gershwin
Journal:  J Autoimmun       Date:  2007-09-21       Impact factor: 7.094

Review 9.  Escape from negative regulation of growth by transforming growth factor beta and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis.

Authors:  A Hague; A M Manning; J W van der Stappen; C Paraskeva
Journal:  Cancer Metastasis Rev       Date:  1993-09       Impact factor: 9.264

10.  Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells.

Authors:  Lakshmi S Chaturvedi; Marc D Basson
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