Literature DB >> 8318333

Effect of age on the sensitivity of upper airway reflexes.

R J Erskine1, P J Murphy, J A Langton, G Smith.   

Abstract

We have recorded the threshold concentration of inhaled ammonia vapour required to elicit reflex glottic closure (NH3TR) in 102 healthy, nonsmoking volunteers (39 female) aged 17-96 yr in order to assess the effect of age upon upper airway reflex sensitivity. A single measurement of sensitivity was made in each subject using a system delivering small concentrations of ammonia vapour for single intermittent breaths to the upper airway and recording glottic closure using an inspiratory pneumotachograph. We found a strong positive correlation between age and NH3TR, indicating a decrease in upper airway reflex sensitivity with increasing age.

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Year:  1993        PMID： 8318333     DOI： 10.1093/bja/70.5.574

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  10 in total

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  10 in total

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