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Literature DB >> 8318166

Genomic damage and its repair in young and aging brain.

Abstract

A brief review of the available information concerning age-related genomic (DNA) damage and its repair, with special reference to brain tissue, is presented. The usefulness of examining the validity of DNA-damage and repair hypothesis of aging in a postmitotic cell like neuron is emphasized. The limited number of reports that exist on brain seem to overwhelmingly support the accumulation of DNA damage with age. However, results regarding the age-dependent decline in DNA-repair capacity are conflicting and divided. The possible reasons for these discrepancies are discussed in light of the gathering evidence, including some human genetic disorders, to indicate how complex is the DNA-repair system in higher animals. It is suggested that assessment of repair potential of neurons with respect to a specific damage in a specific gene might yield more definitive answers about the DNA-repair process and its role in aging.

Entities: Disease Species

Mesh：

Substances：
Chromatin

Year: 1993 PMID： 8318166 DOI： 10.1007/bf02780607

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

107 in total

Review 1. Involvement of DNA repair in cancer and aging.

Authors: H R Warner; A R Price
Journal: J Gerontol Date: 1989-11

2. Neurochemical approaches to the pathogenesis of Down's syndrome.

Authors: R Balazs; B W Brooksbank
Journal: J Ment Defic Res Date: 1985-03

Review 3. DNA damage as the primary cause of aging.

Authors: H L Gensler; H Bernstein
Journal: Q Rev Biol Date: 1981-09 Impact factor: 4.875

4. A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine.

Authors: T C Brown; J Jiricny
Journal: Cell Date: 1987-09-11 Impact factor: 41.582

Review 5. Mismatch repair in mammalian cells.

Authors: L A Heywood; J F Burke
Journal: Bioessays Date: 1990-10 Impact factor: 4.345

6. Processing of psoralen adducts in an active human gene: repair and replication of DNA containing monoadducts and interstrand cross-links.

Authors: J M Vos; P C Hanawalt
Journal: Cell Date: 1987-08-28 Impact factor: 41.582

7. Age associated increase of single-stranded regions in the DNA of mouse brain and liver cells.

Authors: K Nakanishi; A Shima; M Fukuda; S Fujita
Journal: Mech Ageing Dev Date: 1979-05 Impact factor: 5.432

8. Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro.

Authors: L R Barrows; P N Magee
Journal: Carcinogenesis Date: 1982 Impact factor: 4.944

9. The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease.

Authors: F Hennecke; H Kolmar; K Bründl; H J Fritz
Journal: Nature Date: 1991-10-24 Impact factor: 49.962

10. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene.

Authors: I Mellon; G Spivak; P C Hanawalt
Journal: Cell Date: 1987-10-23 Impact factor: 41.582

17 in total

1. DNA damage profiling in motor neurons: a single-cell analysis by comet assay.

Authors: Lee J Martin; Zhiping Liu
Journal: Neurochem Res Date: 2002-10 Impact factor: 3.996

Review 2. DNA damage and repair: relevance to mechanisms of neurodegeneration.

Authors: Lee J Martin
Journal: J Neuropathol Exp Neurol Date: 2008-05 Impact factor: 3.685

3. Omega-3 fatty acid supplementation decreases DNA damage in brain of rats subjected to a chemically induced chronic model of Tyrosinemia type II.

Authors: Milena Carvalho-Silva; Lara M Gomes; Giselli Scaini; Joyce Rebelo; Adriani P Damiani; Maiara Pereira; Vanessa M Andrade; Fernanda F Gava; Samira S Valvassori; Patricia F Schuck; Gustavo C Ferreira; Emilio L Streck
Journal: Metab Brain Dis Date: 2017-03-18 Impact factor: 3.584

4. Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease.

Authors: Laurie H Sanders; Jennifer McCoy; Xiaoping Hu; Pier G Mastroberardino; Bryan C Dickinson; Christopher J Chang; Charleen T Chu; Bennett Van Houten; J T Greenamyre
Journal: Neurobiol Dis Date: 2014-06-27 Impact factor: 5.996

5. Age-related decline in DNA polymerase β activity in rat brain and tissues.

Authors: V N Vyjayanti; Umakanta Swain; Kalluri Subba Rao
Journal: Neurochem Res Date: 2012-01-05 Impact factor: 3.996

6. DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis.

Authors: Arif Y Shaikh; Lee J Martin
Journal: Neuromolecular Med Date: 2002 Impact factor: 3.843

7. Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression.

Authors: Mohammed S Mustak; Muralidhar L Hegde; Athira Dinesh; Gabrielle B Britton; Ruben Berrocal; K Subba Rao; N M Shamasundar; K S J Rao; T S Sathyanarayana Rao
Journal: Indian J Psychiatry Date: 2010-07 Impact factor: 1.759

8. New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions.

Authors: P Vasudevaraju; Jyothsna T; N M Shamasundar; K Subba Rao; B M Balaraj; Rao Ksj; Sathyanarayana Rao T S
Journal: Indian J Psychiatry Date: 2010-04 Impact factor: 1.759

9. L-tyrosine induces DNA damage in brain and blood of rats.

Authors: Samira D T De Prá; Gabriela K Ferreira; Milena Carvalho-Silva; Júlia S Vieira; Giselli Scaini; Daniela D Leffa; Gabriela E Fagundes; Bruno N Bristot; Gabriela D Borges; Gustavo C Ferreira; Patrícia F Schuck; Vanessa M Andrade; Emilio L Streck
Journal: Neurochem Res Date: 2013-12-03 Impact factor: 3.996

Review 10. DNA Damage in Major Psychiatric Diseases.

Authors: Muhammad Ummear Raza; Turan Tufan; Yan Wang; Christopher Hill; Meng-Yang Zhu
Journal: Neurotox Res Date: 2016-04-28 Impact factor: 3.911