Literature DB >> 8318000

A class-A beta-lactamase from Pseudomonas stutzeri that is highly active against monobactams and cefotaxime.

N Franceschini1, M Galleni, J M Frère, A Oratore, G Amicosante.   

Abstract

A beta-lactamase produced by Pseudomonas stutzeri was purified to protein homogeneity, and its physicochemical and catalytic properties were determined. Its profile was unusual since, in addition to penicillins, the enzyme hydrolysed second- and third-generation 'beta-lactamase-stable' cephalosporins and monobactams with similar efficiencies. On the basis of the characteristics of the interaction with beta-iodopenicillanic acid, the enzyme could be classified as a class-A beta-lactamase. However, when compared with most class-A beta-lactamases, it exhibited significantly lower kcat./Km values for the compounds usually considered to be the best substrates of these enzymes.

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Year:  1993        PMID： 8318000      PMCID： PMC1134169          DOI： 10.1042/bj2920697

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

Authors:  F De Meester; B Joris; G Reckinger; C Bellefroid-Bourguignon; J M Frère; S G Waley
Journal:  Biochem Pharmacol       Date:  1987-07-15       Impact factor: 5.858

3.  Citrobacter diversus ULA-27 beta-lactamases. Improved purification and general properties.

Authors:  G Amicosante; A Oratore; N Franceschini; M Maccarrone; R Strom; M Galleni; J M Frère
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  The structure of beta-lactamases.

Authors:  R P Ambler
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1980-05-16       Impact factor: 6.237

6.  Properties of three carbenicillin-hydrolysing beta-lactamases (CARB) from Pseudomonas aeruginosa: identification of a new enzyme.

Authors:  R Labia; M Guionie; M Barthélémy
Journal:  J Antimicrob Chemother       Date:  1981-01       Impact factor: 5.790

7.  Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria.

Authors:  K Bush; J S Freudenberger; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

8.  Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes.

Authors:  W Sougakoff; S Goussard; G Gerbaud; P Courvalin
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

9.  Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.

Authors:  B Joris; P Ledent; O Dideberg; E Fonzé; J Lamotte-Brasseur; J A Kelly; J M Ghuysen; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

10.  Purification of beta-lactamases by affinity chromatography on phenylboronic acid-agarose.

Authors:  S J Cartwright; S G Waley
Journal:  Biochem J       Date:  1984-07-15       Impact factor: 3.857
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  7 in total

Review 1.  Catalytic properties of class A beta-lactamases: efficiency and diversity.

Authors:  A Matagne; J Lamotte-Brasseur; J M Frère
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

Review 2.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

Review 3.  Genetics of extended-spectrum beta-lactamases.

Authors:  G A Jacoby
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994       Impact factor: 3.267

Review 4.  Biology of Pseudomonas stutzeri.

Authors:  Jorge Lalucat; Antoni Bennasar; Rafael Bosch; Elena García-Valdés; Norberto J Palleroni
Journal:  Microbiol Mol Biol Rev       Date:  2006-06       Impact factor: 11.056

Review 5.  Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections.

Authors:  R N Brogden; C M Spencer
Journal:  Drugs       Date:  1997-03       Impact factor: 9.546

6.  Kinetic analysis of extension of substrate specificity with Xanthomonas maltophilia, Aeromonas hydrophila, and Bacillus cereus metallo-beta-lactamases.

Authors:  A Felici; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

Review 7.  AmpC beta-lactamases.

Authors:  George A Jacoby
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132
  7 in total

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