Literature DB >> 8314576

A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

G Lutfalla1, K Gardiner, G Uzé.   

Abstract

A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.

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Year:  1993        PMID： 8314576     DOI： 10.1006/geno.1993.1199

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  16 in total

1.  Identification and functional characterization of a second chain of the interleukin-10 receptor complex.

Authors:  S V Kotenko; C D Krause; L S Izotova; B P Pollack; W Wu; S Pestka
Journal:  EMBO J       Date:  1997-10-01       Impact factor: 11.598

2.  An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation.

Authors:  M Finsterbusch; V Khare; C Campregher; R Evstatiev; C Gasche
Journal:  Genes Immun       Date:  2011-06-09       Impact factor: 2.676

3.  Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.

Authors:  G Lutfalla; M G McInnis; S E Antonarakis; G Uzé
Journal:  J Mol Evol       Date:  1995-09       Impact factor: 2.395

4.  GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16.

Authors:  S Cheng; G Lutfalla; G Uze; I M Chumakov; K Gardiner
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957

5.  A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.

Authors:  W Xu; S R Presnell; J Parrish-Novak; W Kindsvogel; S Jaspers; Z Chen; S R Dillon; Z Gao; T Gilbert; K Madden; S Schlutsmeyer; L Yao; T E Whitmore; Y Chandrasekher; F J Grant; M Maurer; L Jelinek; H Storey; T Brender; A Hammond; S Topouzis; C H Clegg; D C Foster
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

6.  Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster.

Authors:  J Reboul; K Gardiner; D Monneron; G Uzé; G Lutfalla
Journal:  Genome Res       Date:  1999-03       Impact factor: 9.043

7.  Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor beta genotype of donor.

Authors:  Ming-Tseh Lin; Barry Storer; Paul J Martin; Li-Hui Tseng; Bryan Grogan; Pei-Jer Chen; Lue P Zhao; John A Hansen
Journal:  Blood       Date:  2005-08-18       Impact factor: 22.113

Review 8.  Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy.

Authors:  Ankit Saxena; Sam Khosraviani; Sanjeev Noel; Divya Mohan; Thomas Donner; Abdel Rahim A Hamad
Journal:  Cytokine       Date:  2014-12-04       Impact factor: 3.861

9.  The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

Authors:  Josiane Ragimbeau; Elisabetta Dondi; Andrés Alcover; Pierre Eid; Gilles Uzé; Sandra Pellegrini
Journal:  EMBO J       Date:  2003-02-03       Impact factor: 11.598

Review 10.  The molecular basis of IL-10 function: from receptor structure to the onset of signaling.

Authors:  Mark R Walter
Journal:  Curr Top Microbiol Immunol       Date:  2014       Impact factor: 4.291
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