Literature DB >> 8314070

Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy.

J Blangero1, S Williams-Blangero, M C Mahaney.   

Abstract

A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.

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Year:  1993        PMID： 8314070     DOI： 10.1002/gepi.1370100648

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  4 in total

Review 1.  Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.

Authors:  Hemant K Tiwari; Jill Barnholtz-Sloan; Nathan Wineinger; Miguel A Padilla; Laura K Vaughan; David B Allison
Journal:  Hum Hered       Date:  2008-03-31       Impact factor: 0.444

2.  Polymorphisms at the 5'-end of the apolipoprotein AI gene and severity of coronary artery disease.

Authors:  X L Wang; S X Liu; R M McCredie; D E Wilcken
Journal:  J Clin Invest       Date:  1996-07-15       Impact factor: 14.808

3.  A QTL on chromosome 3q23 influences processing speed in humans.

Authors:  Emma E M Knowles; Samuel R Mathias; Josephine Mollon; Amanda Rodrigue; Marinka M G Koenis; Thomas D Dyer; Harald H H Goring; Joanne E Curran; Rene L Olvera; Ravi Duggirala; Laura Almasy; John Blangero; David C Glahn
Journal:  Genes Brain Behav       Date:  2018-11-16       Impact factor: 3.449

4.  Segregation analysis of apolipoprotein A1 levels in families of adolescents: a community-based study in Taiwan.

Authors:  Kuo-Liong Chien; Wei J Chen; Hsiu-Ching Hsu; Ta-Chen Su; Ming-Fong Chen; Yuan-Teh Lee
Journal:  BMC Genet       Date:  2006-01-20       Impact factor: 2.797
  4 in total

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