Literature DB >> 8312496

Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes.

S B Sands1, A C Costa, J W Patrick.   

Abstract

The rat alpha 7 neuronal nicotinic acetylcholine receptor was expressed and studied in Xenopus oocytes. The magnitude and reversal potential of instantaneous whole cell currents were examined in solutions containing varying concentrations of either calcium or barium, and in the presence or absence of the intracellular calcium chelator BAPTA. In external barium, application of nicotine elicits an inwardly rectifying response; in calcium the response is larger and has a linear IV relation. Pretreatment of oocytes with BAPTA-AM could not prevent activation of calcium-dependent chloride channels in external Ringer containing calcium. Using an extended GHK equation, the permeability ratio PBa/PNa of the alpha 7 receptor was determined to be about 17. Our results suggest that alpha 7 nicotinic receptors are highly permeable to divalent cations.

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Year:  1993        PMID： 8312496      PMCID： PMC1226002          DOI： 10.1016/S0006-3495(93)81296-7

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  49 in total

1.  Calcium permeability of neuronal nicotinic acetylcholine receptor channels in PC12 cells.

Authors:  S B Sands; M E Barish
Journal:  Brain Res       Date:  1991-09-27       Impact factor: 3.252

2.  Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations.

Authors:  J A Dani
Journal:  Biophys J       Date:  1986-03       Impact factor: 4.033

3.  Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.

Authors:  J Egebjerg; S F Heinemann
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

4.  Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system.

Authors:  D Goldman; E Deneris; W Luyten; A Kochhar; J Patrick; S Heinemann
Journal:  Cell       Date:  1987-03-27       Impact factor: 41.582

5.  A transient calcium-dependent chloride current in the immature Xenopus oocyte.

Authors:  M E Barish
Journal:  J Physiol       Date:  1983-09       Impact factor: 5.182

6.  Acetylcholine-induced current fluctuations and fast excitatory post-synaptic currents in rabbit sympathetic neurones.

Authors:  V A Derkach; A A Selyanko; V I Skok
Journal:  J Physiol       Date:  1983-03       Impact factor: 5.182

7.  Inward rectification of acetylcholine-elicited currents in rat phaeochromocytoma cells.

Authors:  C K Ifune; J H Steinbach
Journal:  J Physiol       Date:  1992-11       Impact factor: 5.182

8.  Calcium permeability and modulation of nicotinic acetylcholine receptor-channels in rat parasympathetic neurons.

Authors:  D J Adams; T J Nutter
Journal:  J Physiol Paris       Date:  1992

9.  Acetylcholine dose-response relation and the effect of cesium ions in the rat adrenal chromaffin cell under voltage clamp.

Authors:  T Hirano; Y Kidokoro; H Ohmori
Journal:  Pflugers Arch       Date:  1987-04       Impact factor: 3.657

10.  Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.

Authors:  P Hess; J B Lansman; R W Tsien
Journal:  J Gen Physiol       Date:  1986-09       Impact factor: 4.086
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  15 in total

1.  Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors.

Authors:  Clark A Briggs; Jens Halvard Grønlien; Peter Curzon; Daniel B Timmermann; Hilde Ween; Kirsten Thorin-Hagene; Paige Kerr; David J Anderson; John Malysz; Tino Dyhring; Gunnar M Olsen; Dan Peters; William H Bunnelle; Murali Gopalakrishnan
Journal:  Br J Pharmacol       Date:  2009-10-20       Impact factor: 8.739

2.  Improved technique for studying ion channels expressed in Xenopus oocytes, including fast superfusion.

Authors:  A C Costa; J W Patrick; J A Dani
Journal:  Biophys J       Date:  1994-07       Impact factor: 4.033

Review 3.  Elevation of intracellular calcium levels in neurons by nicotinic acetylcholine receptors.

Authors:  M M Rathouz; S Vijayaraghavan; D K Berg
Journal:  Mol Neurobiol       Date:  1996-04       Impact factor: 5.590

4.  Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response.

Authors:  A Figl; N Viseshakul; N Shafaee; J Forsayeth; B N Cohen
Journal:  J Physiol       Date:  1998-12-15       Impact factor: 5.182

5.  Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A.

Authors:  Romulo Araoz; Denis Servent; Jordi Molgó; Bogdan I Iorga; Carole Fruchart-Gaillard; Evelyne Benoit; Zhenhua Gu; Craig Stivala; Armen Zakarian
Journal:  J Am Chem Soc       Date:  2011-06-17       Impact factor: 15.419

Review 6.  α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.

Authors:  Victor V Uteshev
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

7.  Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes.

Authors:  J P Boorman; P J Groot-Kormelink; L G Sivilotti
Journal:  J Physiol       Date:  2000-12-15       Impact factor: 5.182

8.  alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability.

Authors:  N G Castro; E X Albuquerque
Journal:  Biophys J       Date:  1995-02       Impact factor: 4.033

9.  Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors.

Authors:  Paul J Groot-Kormelink; Steven D Broadbent; James P Boorman; Lucia G Sivilotti
Journal:  J Gen Physiol       Date:  2004-05-17       Impact factor: 4.086

10.  Curcumin Acts as a Positive Allosteric Modulator of α7-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain.

Authors:  Eslam Gaber El Nebrisi; Deniz Bagdas; Wisam Toma; Halima Al Samri; Anna Brodzik; Yasmin Alkhlaif; Keun-Hang Susan Yang; Frank Christopher Howarth; Imad M Damaj; Murat Oz
Journal:  J Pharmacol Exp Ther       Date:  2018-01-16       Impact factor: 4.030
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