OBJECTIVES: To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS: TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. RESULTS: No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE. CONCLUSIONS: These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
OBJECTIVES: To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS:TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. RESULTS: No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE. CONCLUSIONS: These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
Authors: S J Powis; E V Deverson; W J Coadwell; A Ciruela; N S Huskisson; H Smith; G W Butcher; J C Howard Journal: Nature Date: 1992-05-21 Impact factor: 49.962
Authors: M Galeazzi; G D Sebastiani; G Passiu; G Angelini; L Delfino; R A Asherson; M A Khamashta; G R Hughes Journal: J Rheumatol Date: 1992-01 Impact factor: 4.666
Authors: E M Tan; A S Cohen; J F Fries; A T Masi; D J McShane; N F Rothfield; J G Schaller; N Talal; R J Winchester Journal: Arthritis Rheum Date: 1982-11
Authors: J M Martín-Villa; J Martínez-Laso; M A Moreno-Pelayo; M J Castro-Panete; N Martínez-Quiles; M Alvarez; M D de Juan; J J Gómez-Reino; A Arnaiz-Villena Journal: Ann Rheum Dis Date: 1998-04 Impact factor: 19.103