Literature DB >> 12827444

Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan.

Chung-Ming Huang1, Liang-Wen Hang, Chi-Lan Chen, Jer-Yuarn Wu, Fuu-Jen Tsai.   

Abstract

The aim of this study was to determine how polymorphisms of transporters associated with transporter and antigen processing 1 (TAP1) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. We collected 88 patients with SLE and 104 healthy people for the control group. The polymorphisms were detected as a result of polymerase chain reaction (PCR)-based restriction analysis. Associations between SLE and TAP1 polymorphisms were evaluated. The results revealed no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (Acc I) polymorphisms ( P=0.10 and 0.36, respectively). However, the G alleles of TAP1-1 and TAP1-2 were significantly more common than the A alleles in serositis of SLE patients (chi(2)=11.16 and P=0.004, chi(2)=8.10 and P=0.02, respectively).

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12827444     DOI： 10.1007/s00296-003-0338-8

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  19 in total

1.  Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

Authors:  S J Powis; E V Deverson; W J Coadwell; A Ciruela; N S Huskisson; H Smith; G W Butcher; J C Howard
Journal:  Nature       Date:  1992-05-21       Impact factor: 49.962

2.  Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells.

Authors:  M S Malnati; M Marti; T LaVaute; D Jaraquemada; W Biddison; R DeMars; E O Long
Journal:  Nature       Date:  1992-06-25       Impact factor: 49.962

Review 3.  Antigen presentation: structural themes and functional variations.

Authors:  T J Braciale; V L Braciale
Journal:  Immunol Today       Date:  1991-04

Review 4.  Systemic lupus erythematosus.

Authors:  B L Kotzin
Journal:  Cell       Date:  1996-05-03       Impact factor: 41.582

5.  HLA and TAP associations in Chinese systemic lupus erythematosus patients.

Authors:  D A Savage; S C Ng; H S Howe; J L Ngai; C Darke; K M Hui
Journal:  Tissue Antigens       Date:  1995-09

6.  Letter: Systemic lupus erythematosus and Klinefelter's syndrome.

Authors:  P R Burch; N R Rowell
Journal:  Lancet       Date:  1976-05-08       Impact factor: 79.321

7.  Lack of association of interleukin-1beta gene polymorphisms in Chinese patients with systemic lupus erythematosus.

Authors:  Chung-Ming Huang; Mei-Chen Wu; Jer-Yuarn Wu; Fuu-Jen Tsai
Journal:  Rheumatol Int       Date:  2002-03       Impact factor: 2.631

8.  Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes.

Authors:  M Carrington; M Colonna; T Spies; J C Stephens; D L Mann
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

9.  Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Authors:  A H Fielder; M J Walport; J R Batchelor; R I Rynes; C M Black; I A Dodi; G R Hughes
Journal:  Br Med J (Clin Res Ed)       Date:  1983-02-05

10.  No association of vitamin D receptor gene start codon fok 1 polymorphisms in Chinese patients with systemic lupus erythematosus.

Authors:  Chung-Ming Huang; Mei-Chen Wu; Jer-Yuarn Wu; Fuu-Jen Tsai
Journal:  J Rheumatol       Date:  2002-06       Impact factor: 4.666
View more
  1 in total

Review 1.  Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis.

Authors:  Yufeng Qian; Genlin Wang; Feng Xue; Lianghui Chen; Yan Wang; Liang Tang; Huilin Yang
Journal:  Inflamm Res       Date:  2017-04-12       Impact factor: 4.575
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.