Literature DB >> 8310449

Distribution and elimination of ingested brevetoxin (PbTx-3) in rats.

M Cattet1, J R Geraci.   

Abstract

As a first step towards understanding the pathologic effects of ingested brevetoxin (PbTx) in marine mammals, we determined how [3H]PbTx-3 was distributed and eliminated when ingested at sub-lethal dosages (18.6 micrograms/kg) by Fischer 344 rats. Brevetoxin was distributed widely in the body, but concentrated primarily in the liver. It was eliminated in equivalent quantities through the urine and feces. However, we believe urinary clearance is the primary route for PbTx-3 absorbed from the gastrointestinal tract.

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Year:  1993        PMID： 8310449     DOI： 10.1016/0041-0101(93)90214-4

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  21 in total

1.  Immune function in Trachemys scripta following exposure to a predominant brevetoxin congener, PbTx-3, as a model for potential health impacts for sea turtles naturally exposed to brevetoxins.

Authors:  Catherine J Walsh; Courtney Cocilova; Jessica Restivo; Leanne Flewelling; Sarah Milton
Journal:  Ecotoxicology       Date:  2019-09-26       Impact factor: 2.823

2.  Placental transport of brevetoxin-3 in CD-1 mice.

Authors:  Janet M Benson; Andrea P Gomez; Gloria L Statom; Brad M Tibbetts; Lora E Fleming; Lorraine C Backer; Andrew Reich; Daniel G Baden
Journal:  Toxicon       Date:  2006-08-18       Impact factor: 3.033

3.  Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain.

Authors:  Xiuzhen Yan; Janet M Benson; Andrea P Gomez; Daniel G Baden; Thomas F Murray
Journal:  Inhal Toxicol       Date:  2006-12       Impact factor: 2.724

4.  Cochlear function in mice following inhalation of brevetoxin-3.

Authors:  Janet M Benson; Barden B Stagner; Glen K Martin; Melissa Friedman; Sarah E Durr; Andrea Gomez; Jacob McDonald; Lora E Fleming; Lorraine C Backer; Daniel G Baden; Andrea Bourdelais; Jerome Naar; Brenda L Lonsbury-Martin
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2005-05-18       Impact factor: 1.836

5.  Uptake, tissue distribution, and excretion of brevetoxin-3 administered to mice by intratracheal instillation.

Authors:  Brad M Tibbetts; Daniel G Baden; Janet M Benson
Journal:  J Toxicol Environ Health A       Date:  2006-07

6.  Human metabolites of brevetoxin PbTx-2: Identification and confirmation of structure.

Authors:  Fujiang Guo; Tianying An; Kathleen S Rein
Journal:  Toxicon       Date:  2010-06-17       Impact factor: 3.033

7.  Literature Review of Florida Red Tide: Implications for Human Health Effects.

Authors:  Barbara Kirkpatrick; Lora E Fleming; Dominick Squicciarini; Lorrie C Backer; Richard Clark; William Abraham; Janet Benson; Yung Sung Cheng; David Johnson; Richard Pierce; Julia Zaias; Gregory D Bossart; Daniel G Baden
Journal:  Harmful Algae       Date:  2004-04-01       Impact factor: 4.273

8.  Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons.

Authors:  Shashank M Dravid; Daniel G Baden; Thomas F Murray
Journal:  J Neurochem       Date:  2004-05       Impact factor: 5.372

9.  Inhalation toxicity of brevetoxin 3 in rats exposed for 5 days.

Authors:  Janet Benson; Fletcher Hahn; Thomas March; Jacob McDonald; Mohan Sopori; JeanClare Seagrave; Andrea Gomez; Andrea Bourdelais; Jerome Naar; Julia Zaias; Gregory Bossart; Daniel Baden
Journal:  J Toxicol Environ Health A       Date:  2004-09-24

10.  Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways.

Authors:  Zhengyu Cao; Joju George; Daniel G Baden; Thomas F Murray
Journal:  Brain Res       Date:  2007-10-04       Impact factor: 3.252
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