Literature DB >> 20600229

Human metabolites of brevetoxin PbTx-2: Identification and confirmation of structure.

Fujiang Guo1, Tianying An, Kathleen S Rein.   

Abstract

Four metabolites were identified upon incubation of brevetoxin (PbTx-2) with human liver microsomes. Chemical transformation of PbTx-2 confirmed the structures of three known metabolites BTX-B5, PbTx-9 and 41, 43-dihydro-BTX-B5 and a previously unknown metabolite, 41, 43-dihydro-PbTx-2. These metabolites were also observed upon incubation of PbTx-2 with nine human recombinant cytochrome P450s (1A1, 1A2, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5). Cytochrome P450 3A4 produced oxidized metabolites while other CYPs generated the reduced products. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20600229      PMCID： PMC2909374          DOI： 10.1016/j.toxicon.2010.06.007

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  11 in total

1.  Distribution and elimination of brevetoxin PbTx-3 in rats.

Authors:  M A Poli; C B Templeton; W L Thompson; J F Hewetson
Journal:  Toxicon       Date:  1990       Impact factor: 3.033

2.  Synthesis, modeling, and biological evaluation of analogues of the semisynthetic brevetoxin antagonist beta-naphthoyl-brevetoxin.

Authors:  Sophie Michelliza; William M Abraham; Henry M Jacocks; Thomas Schuster; Daniel G Baden
Journal:  Chembiochem       Date:  2007-12-17       Impact factor: 3.164

3.  Neurotoxic shellfish poisoning and brevetoxin metabolites: a case study from Florida.

Authors:  M A Poli; S M Musser; R W Dickey; P P Eilers; S Hall
Journal:  Toxicon       Date:  2000-07       Impact factor: 3.033

4.  Characterization of in vitro oxidative and conjugative metabolic pathways for brevetoxin (PbTx-2).

Authors:  Faisal F Y Radwan; John S Ramsdell
Journal:  Toxicol Sci       Date:  2005-10-12       Impact factor: 4.849

5.  Identification of a rapid detoxification mechanism for brevetoxin in rats.

Authors:  Faisal F Y Radwan; Zhihong Wang; John S Ramsdell
Journal:  Toxicol Sci       Date:  2005-03-02       Impact factor: 4.849

6.  Biomarkers of neurotoxic shellfish poisoning.

Authors:  Ann Abraham; Steven M Plakas; Leanne J Flewelling; Kathleen R El Said; Edward L E Jester; Hudson R Granade; Kevin D White; Robert W Dickey
Journal:  Toxicon       Date:  2008-05-29       Impact factor: 3.033

7.  Distribution and elimination of ingested brevetoxin (PbTx-3) in rats.

Authors:  M Cattet; J R Geraci
Journal:  Toxicon       Date:  1993-11       Impact factor: 3.033

8.  Fate and distribution of brevetoxin (PbTx) following lysis of Karenia brevis by algicidal bacteria, including analysis of open A-ring derivatives.

Authors:  Patricia B Roth; Michael J Twiner; Zhihong Wang; Marie-Yasmine Bottein Dechraoui; Gregory J Doucette
Journal:  Toxicon       Date:  2007-08-14       Impact factor: 3.033

9.  Overview of aerosolized Florida red tide toxins: exposures and effects.

Authors:  Lora E Fleming; Lorraine C Backer; Daniel G Baden
Journal:  Environ Health Perspect       Date:  2005-05       Impact factor: 9.031

Review 10.  Neurotoxic shellfish poisoning.

Authors:  Sharon M Watkins; Andrew Reich; Lora E Fleming; Roberta Hammond
Journal:  Mar Drugs       Date:  2008-07-12       Impact factor: 5.118
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  2 in total

1.  Cellular and transcriptional responses of Crassostrea gigas hemocytes exposed in vitro to brevetoxin (PbTx-2).

Authors:  Danielle F Mello; Eliza S De Oliveira; Renato C Vieira; Erik Simoes; Rafael Trevisan; Alcir Luiz Dafre; Margherita Anna Barracco
Journal:  Mar Drugs       Date:  2012-03-05       Impact factor: 6.085

Review 2.  Chemodiversity of Brevetoxins and Other Potentially Toxic Metabolites Produced by Karenia spp. and Their Metabolic Products in Marine Organisms.

Authors:  Vincent Hort; Eric Abadie; Nathalie Arnich; Marie-Yasmine Dechraoui Bottein; Zouher Amzil
Journal:  Mar Drugs       Date:  2021-11-24       Impact factor: 5.118
  2 in total

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