| Literature DB >> 3257870 |
S C Gilman1, J Chang, P R Zeigler, J Uhl, E Mochan.
Abstract
Interleukin-1 (IL-1) treatment of synovial cells from rheumatoid arthritis and osteoarthritis patients resulted in a dose-dependent secretion of phospholipase A2 (PLA2). IL-1 also stimulated prostaglandin E2 and plasminogen activator synthesis, in parallel with PLA2 activation; all 3 were detectable within 6 hours of IL-1 treatment and peaked by 24 hours. Synovial cell PLA2 required calcium (5 mM) and a neutral pH (7.5) for maximal activity and appears similar to the PLA2 in synovial fluid, which has been described previously. We conclude that PLA2 can be induced by IL-1, and its secretion may contribute significantly to the inflammatory actions of IL-1.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3257870 DOI： 10.1002/art.1780310118
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591