Literature DB >> 829902

Genetics of mouse antibodies. II. Recombination between VH genes and allotype.

R Riblet, M Weigert, O Mäkelä.   

Abstract

The BAB/14 (BALB/c. C57BL/Ka-Ig-1b/HZ) congenic mouse strain was found to respond to (4-hydroxy-3-nitrophenyl)acetyl (NP)-chicken globulin immunization with nonheteroclitic anti-NP antibodies as does the BALB/c inbred partner strain. This is in contrast to the heteroclitic anti-NP response of the C57BL/Ka allotype donor strain and indicates that the allotype linked VH-NP gene was inherited with the VH-DEX gene from BALB/C rather than with the allotype genes from C57BL/Ka. This verifies the interpretation of BAB/14 as an immunoglobulin gene recombinant. Two recombinants between VH-DEX and Ig-1 allogype genes have been found among 554 chromosomes tested yielding a recombination frequency of 0.4%. Analysis of the BAB/14 recombinant showed that this crossover occurred between VH genes implying that VH genes and CH genes are not organized in separate clusters separated by a larger spacer region but are contiguous. Analysis of the recombination frequencies indicates that the total number of VH genes must be at least 50.

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Year:  1975        PMID： 829902     DOI： 10.1002/eji.1830051110

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  11 in total

1.  Genetics of the anti-dextran B512 and the autoanti-idiotypic response: codominant expression in F1 hybrids and dichotomy of response and allotype-linked idiotype.

Authors:  C Fernandez; O Mäkelä; G Möller
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

2.  The genetic control of the immune response to staphylococcal nuclease VI. Recombination between genes determining the A/J anti-nuclease idiotypes and the heavy chain allotype locus.

Authors:  D S Pisetsky; D H Sachs
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

3.  Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

Authors:  J A Laskin; A Gray; A Nisonoff; N R Klinman; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

4.  Immunoglobulin isoantigens (allotypes) in the mouse : V. Characterization of IgM allotypes.

Authors:  S J Black; J W Goding; G A Gutman; L A Herzenberg; M R Loken; B A Osborne; W van der Loo; N L Warner
Journal:  Immunogenetics       Date:  1978-12       Impact factor: 2.846

5.  Regulation of the production of murine IgG2a by an H-2-linked gene and other unlinked genes.

Authors:  A P Dowsett; L A Herzenberg; L A Herzenberg
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

6.  Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes.

Authors:  J Z Weinberger; M I Greene; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

7.  Linkage between the frequency of muscular weakness and loci that regulate immune responsiveness in murine experimental myasthenia gravis.

Authors:  P W Berman; J Patrick
Journal:  J Exp Med       Date:  1980-09-01       Impact factor: 14.307

8.  Genetics of the idotype of BALB/c myeloma S117: multiple chromosomal loci for Vh genes encoding specificity for group A streptococcal carbohydrate.

Authors:  C Berek; B A Taylor; K Eichmann
Journal:  J Exp Med       Date:  1976-11-02       Impact factor: 14.307

9.  Idiotype-specific T lymphocytes. II. capability of generation of idiotype-specific T lymphocytes is determined by corresponding VH gene.

Authors:  H Yamamoto; S Bitoh; S Fujimoto
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

10.  Strain-specific silencing of a predominant antidextran clonotype family.

Authors:  B G Froscher; N R Klinman
Journal:  J Exp Med       Date:  1985-11-01       Impact factor: 14.307
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