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Literature DB >> 8298816

Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT.

Abstract

5-Hydroxytryptamine increases transmucosal short-circuit current across human isolated small intestinal mucosa. The competitive 5-HT4 antagonist, DAU 6285 evoked a concentration-dependent, dextral and parallel shift of the concentration-response curve to 5-HT, with no alteration of the maximum response. Schild analysis of this antagonism produced a Schild regression with a slope of 1.00 and an apparent pA2 estimate of 6.17. It appears that a 5-HT4 receptor may mediate the short-circuit current response of human small intestinal mucosa to 5-HT.

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Year: 1993 PMID： 8298816 PMCID： PMC2175779 DOI： 10.1111/j.1476-5381.1993.tb13901.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

7 in total

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Authors: J Bockaert; J R Fozard; A Dumuis; D E Clarke
Journal: Trends Pharmacol Sci Date: 1992-04 Impact factor: 14.819

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Authors: A Schiavone; E Giraldo; L Giudici; M Turconi; A Sagrada
Journal: Life Sci Date: 1992 Impact factor: 5.037

3. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

4. Loperamide but not morphine has anti-secretory effects in human colon, in vitro.

Authors: D E Burleigh
Journal: Eur J Pharmacol Date: 1991-09-17 Impact factor: 4.432

5. Pharmacological analyses of endo-6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1 H- benzimidazole-1-carboxylate hydrochloride (DAU 6285) at the 5-hydroxytryptamine4 receptor in the tunica muscularis mucosae of rat esophagus and ileum of guinea pig: role of endogenous 5-hydroxytryptamine.

Authors: M V Waikar; S S Hegde; A P Ford; D E Clarke
Journal: J Pharmacol Exp Ther Date: 1993-02 Impact factor: 4.030

6. Investigation of the 5-hydroxytryptamine receptor mediating the 'maintained' short-circuit current response in guinea-pig ileal mucosa.

Authors: C M Scott; K T Bunce; C F Spraggs
Journal: Br J Pharmacol Date: 1992-08 Impact factor: 8.739

7. Investigation of the 5-hydroxytryptamine receptor mechanism mediating the short-circuit current response in rat colon.

Authors: K T Bunce; C J Elswood; M T Ball
Journal: Br J Pharmacol Date: 1991-04 Impact factor: 8.739

7 in total

17 in total

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Authors: N H Prins; N P Shankley; N J Welsh; M R Briejer; R A Lefebvre; L M Akkermans; J A Schuurkes
Journal: Br J Pharmacol Date: 2000-04 Impact factor: 8.739

Review 2. Serotonergic modulating drugs for functional gastrointestinal diseases.

Authors: Robin Spiller
Journal: Br J Clin Pharmacol Date: 2002-07 Impact factor: 4.335

Review 3. Pharmacology of serotonin: what a clinician should know.

Authors: F De Ponti
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4. Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium.

Authors: G P Leung; S L Dun; N J Dun; P Y Wong
Journal: J Physiol Date: 1999-09-15 Impact factor: 5.182

5. Increased defecation during stress or after 5-hydroxytryptophan: selective inhibition by the 5-HT(4) receptor antagonist, SB-207266.

Authors: G J Sanger; M Yoshida; M Yahyah; K Kitazumi
Journal: Br J Pharmacol Date: 2000-06 Impact factor: 8.739

9. Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle.

Authors: F S Tam; K Hillier; K T Bunce; C Grossman
Journal: Br J Pharmacol Date: 1995-05 Impact factor: 8.739

Review 10. Role of serotonin in the pathophysiology of the irritable bowel syndrome.

Authors: Michael D Crowell
Journal: Br J Pharmacol Date: 2004-04 Impact factor: 8.739