Literature DB >> 7599919

Functional evidence for a 5-HT2B receptor mediating contraction of longitudinal muscle in human small intestine.

R A Borman1, D E Burleigh.   

Abstract

Application of 5-hydroxytryptamine induces contraction of longitudinal muscle strips from human terminal ileum. The response was resistant to antagonism by ketanserin, ondansetron or DAU6285, but was non-surmountably antagonized by methysergide. The selective 5-HT2B/2C receptor antagonist, SB 200646A evoked a concentration-dependent, parallel and dextral displacement of the concentration-response curve to 5-HT, yielding a pA2 estimate of 7.17. Application of yohimbine, a 5-HT1 and 5-HT2B receptor antagonist, also induced a rightward shift of the response curve to 5-HT, yielding a pA2 estimate of 8.10. In conclusion, it appears that a 5-HT2B receptor mediates the contractile response of the longitudinal muscle of human small intestine to 5-HT.

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Year:  1995        PMID： 7599919      PMCID： PMC1510406          DOI： 10.1111/j.1476-5381.1995.tb14935.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus.

Authors:  J D Kursar; D L Nelson; D B Wainscott; M L Cohen; M Baez
Journal:  Mol Pharmacol       Date:  1992-10       Impact factor: 4.436

2.  New mouse 5-HT2-like receptor. Expression in brain, heart and intestine.

Authors:  S Loric; J M Launay; J F Colas; L Maroteaux
Journal:  FEBS Lett       Date:  1992-11-09       Impact factor: 4.124

3.  DAU 6285: a novel antagonist at the putative 5-HT4 receptor.

Authors:  A Schiavone; E Giraldo; L Giudici; M Turconi; A Sagrada
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

4.  Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT.

Authors:  R A Borman; D E Burleigh
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

5.  Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle.

Authors:  G S Baxter; O E Murphy; T P Blackburn
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

6.  In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist.

Authors:  G A Kennett; M D Wood; A Glen; S Grewal; I Forbes; A Gadre; T P Blackburn
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

7.  Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

Authors:  J D Kursar; D L Nelson; D B Wainscott; M Baez
Journal:  Mol Pharmacol       Date:  1994-08       Impact factor: 4.436
  7 in total
  5 in total

1.  The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Authors:  J A M Smith; D T Beattie; D Marquess; J P Shaw; R G Vickery; P P A Humphrey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-04-16       Impact factor: 3.000

2.  RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist.

Authors:  D W Bonhaus; L A Flippin; R J Greenhouse; S Jaime; C Rocha; M Dawson; K Van Natta; L K Chang; T Pulido-Rios; A Webber; E Leung; R M Eglen; G R Martin
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

3.  A quantitative systems pharmacology model of colonic motility with applications in drug development.

Authors:  Raibatak Das; Lucia Wille; Liming Zhang; Chunlin Chen; Wendy Winchester; Jangir Selimkhanov; Jill Wykosky; Joshua F Apgar; John M Burke; Mark Rogge; Fei Hua; Majid Vakilynejad
Journal:  J Pharmacokinet Pharmacodyn       Date:  2019-08-20       Impact factor: 2.745

4.  5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro.

Authors:  R A Borman; N S Tilford; D W Harmer; N Day; E S Ellis; R L G Sheldrick; J Carey; R A Coleman; G S Baxter
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

Review 5.  Serotonin pharmacology in the gastrointestinal tract: a review.

Authors:  D T Beattie; J A M Smith
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-04-09       Impact factor: 3.000
  5 in total

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