Literature DB >> 8291253

Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line.

Z Mĕlková1, M Esteban.   

Abstract

Interferon-gamma inhibits the growth of several viruses; however, the exact mechanism of this inhibition has not been clearly defined. In this report, we show that in a monocyte/macrophage cell line J774.G8 IFN-gamma inhibits the growth of vaccinia virus (VV) in a dose-dependent manner. This inhibition is due to a block in VV DNA synthesis and correlates with an increased generation of reactive nitrogen intermediates.

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Year:  1994        PMID： 8291253     DOI： 10.1006/viro.1994.1087

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  16 in total

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5.  JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase.

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6.  Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity.

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Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

7.  Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication.

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Review 8.  Functional organization of variola major and vaccinia virus genomes.

Authors:  S N Shchelkunov
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Authors:  Donald Y M Leung; Pei-Song Gao; Dmitry N Grigoryev; Nicholas M Rafaels; Joanne E Streib; Michael D Howell; Patricia A Taylor; Mark Boguniewicz; Jennifer Canniff; Brian Armstrong; Daniel J Zaccaro; Lynda C Schneider; Tissa R Hata; Jon M Hanifin; Lisa A Beck; Adriana Weinberg; Kathleen C Barnes
Journal:  J Allergy Clin Immunol       Date:  2011-04       Impact factor: 10.793

10.  Novel cell type-specific antiviral mechanism of interferon gamma action in macrophages.

Authors:  R M Presti; D L Popkin; M Connick; S Paetzold; H W Virgin
Journal:  J Exp Med       Date:  2001-02-19       Impact factor: 14.307
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