Literature DB >> 8287274

Liposome targeting to rat brain: effect of osmotic opening of the blood-brain barrier.

A Sakamoto1, T Ido.   

Abstract

To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or without osmotic treatment by mannitol, we administered liposomes through the internal carotid artery in rats. Sulfatide liposomes could pass the BBB with osmotic treatment, but not without osmotic treatment. Therefore, we propose that the combination method of administration of the reticuloendothelial-system avoiding liposomes with osmotic treatment can be useful for treatment of various kinds of brain diseases.

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Year:  1993        PMID： 8287274     DOI： 10.1016/0006-8993(93)90499-d

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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2.  Brain drug delivery of small molecules using immunoliposomes.

Authors:  J Huwyler; D Wu; W M Pardridge
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9.  Molecular imaging of brain localization of liposomes in mice using MALDI mass spectrometry.

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  9 in total

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