Literature DB >> 31588177

Nanotherapeutics Engineered to Cross the Blood-Brain Barrier for Advanced Drug Delivery to the Central Nervous System.

Jinhwan Kim1, Song Ih Ahn1, YongTae Kim1.   

Abstract

Drug delivery to the brain remains challenging mainly due to the blood-brain barrier (BBB) that regulates the entrance of substances to the brain. Advances in nanotechnology have enabled the engineering of nanomedicines for biomedical applications including enhanced drug delivery into the brain. In this review, we describe strategies of nanomedicines engineered to traverse the BBB and deliver therapeutic molecules to target brain sites. We highlight the representative applications with materials including polymers, lipids, and inorganic elements for brain drug delivery. We finalize this review with the current challenges and future perspective of nanotherapeutics for advanced drug delivery to the brain.

Entities:  

Keywords:  blood-brain barrier; brain disease; drug delivery; engineered nanoparticles; nanomedicine

Year:  2019        PMID： 31588177      PMCID： PMC6777578          DOI： 10.1016/j.jiec.2019.01.021

Source DB:  PubMed          Journal:  J Ind Eng Chem        ISSN： 1226-086X            Impact factor:   6.064


  107 in total

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Review 5.  Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases.

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6.  Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery.

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7.  C60 fullerene derivatized nanoparticles and their application to therapeutics.

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Review 8.  Blood-brain barrier drug targeting: the future of brain drug development.

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Authors:  Jiangbing Zhou; Toral R Patel; Rachael W Sirianni; Garth Strohbehn; Ming-Qiang Zheng; Nha Duong; Thomas Schafbauer; Anita J Huttner; Yiyun Huang; Richard E Carson; Ying Zhang; David J Sullivan; Joseph M Piepmeier; W Mark Saltzman
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-01       Impact factor: 11.205

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Journal:  ACS Nano       Date:  2015-10-12       Impact factor: 15.881
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  12 in total

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Review 2.  Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery.

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Review 3.  In search of effective therapies to overcome resistance to Temozolomide in brain tumours.

Authors:  Kaouthar Bouzinab; Helen Summers; Jihong Zhang; Malcolm F G Stevens; Christopher J Moody; Lyudmila Turyanska; Neil R Thomas; Pavel Gershkovich; Marianne B Ashford; Emily Vitterso; Lisa C D Storer; Richard Grundy; Tracey D Bradshaw
Journal:  Cancer Drug Resist       Date:  2019-12-19

4.  Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma.

Authors:  Jinhwan Kim; Abhinav Dey; Anshu Malhotra; Jingbo Liu; Song Ih Ahn; Yoshitaka J Sei; Anna M Kenney; Tobey J MacDonald; YongTae Kim
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5.  Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms.

Authors:  Song Ih Ahn; Yoshitaka J Sei; Hyun-Ji Park; Jinhwan Kim; Yujung Ryu; Jeongmoon J Choi; Hak-Joon Sung; Tobey J MacDonald; Allan I Levey; YongTae Kim
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Review 8.  Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics.

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Journal:  Biomedicines       Date:  2020-01-13

9.  Transplantation of bioengineered Reelin-loaded PLGA/PEG micelles can accelerate neural tissue regeneration in photothrombotic stroke model of mouse.

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10.  Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental.

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