Literature DB >> 8285703

Nutritional aspects of cytotoxin production by Clostridium difficile.

D P Osgood1, N P Wood, J F Sperry.   

Abstract

Arginine was the only amino acid used by Clostridium difficile that permitted cytotoxin synthesis in a peptone-based medium. Synthesis of cytotoxin was delayed when glucose was used as the substrate. Addition of rifampin or puromycin to cultures prior to release of cytotoxin inhibited the release of cytotoxin, suggesting that a protein essential for cytotoxin release is synthesized after cytotoxin is synthesized.

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Year:  1993        PMID： 8285703      PMCID： PMC195856          DOI： 10.1128/aem.59.12.3985-3988.1993

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  The estimation of arginine.

Authors:  H ROSENBERG; A H ENNOR; J F MORRISON
Journal:  Biochem J       Date:  1956-05       Impact factor: 3.857

2.  Nucleotide sequence of Clostridium difficile toxin B gene.

Authors:  L A Barroso; S Z Wang; C J Phelps; J L Johnson; T D Wilkins
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971

3.  Cytotoxicity assay in antibiotic-associated colitis.

Authors:  T W Chang; M Lauermann; J G Bartlett
Journal:  J Infect Dis       Date:  1979-11       Impact factor: 5.226

4.  Purification and properties of Clostridium difficile cytotoxin B.

Authors:  C Pothoulakis; L M Barone; R Ely; B Faris; M E Clark; C Franzblau; J T LaMont
Journal:  J Biol Chem       Date:  1986-01-25       Impact factor: 5.157

5.  Treatment of Clostridium difficile colitis.

Authors:  J G Bartlett
Journal:  Gastroenterology       Date:  1985-11       Impact factor: 22.682

6.  Production and release of toxins A and B by Clostridium difficile.

Authors:  J M Ketley; S C Haslam; T J Mitchell; J Stephen; D C Candy; D W Burdon
Journal:  J Med Microbiol       Date:  1984-12       Impact factor: 2.472

7.  Effects of Clostridium difficile toxin on tissue-cultured cells.

Authors:  S T Donta; S J Shaffer
Journal:  J Infect Dis       Date:  1980-02       Impact factor: 5.226

8.  Comparison of two toxins produced by Clostridium difficile.

Authors:  N S Taylor; G M Thorne; J G Bartlett
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

9.  Purification and characterization of Clostridium difficile toxin.

Authors:  R D Rolfe; S M Finegold
Journal:  Infect Immun       Date:  1979-07       Impact factor: 3.441

10.  Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis.

Authors:  K H Kim; R Fekety; D H Batts; D Brown; M Cudmore; J Silva; D Waters
Journal:  J Infect Dis       Date:  1981-01       Impact factor: 5.226
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  12 in total

1.  Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests.

Authors:  Aiqi Fang; Donald F Gerson; Arnold L Demain
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-27       Impact factor: 11.205

2.  Toxins, butyric acid, and other short-chain fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile.

Authors:  S Karlsson; A Lindberg; E Norin; L G Burman; T Akerlund
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

3.  Analysis of proline reduction in the nosocomial pathogen Clostridium difficile.

Authors:  Sarah Jackson; Mary Calos; Andrew Myers; William T Self
Journal:  J Bacteriol       Date:  2006-10-13       Impact factor: 3.490

Review 4.  Integration of metabolism and virulence in Clostridium difficile.

Authors:  Laurent Bouillaut; Thomas Dubois; Abraham L Sonenshein; Bruno Dupuy
Journal:  Res Microbiol       Date:  2014-10-15       Impact factor: 3.992

5.  Multiple factors contribute to bimodal toxin gene expression in Clostridioides (Clostridium) difficile.

Authors:  Eric M Ransom; Gabriela M Kaus; Phuong M Tran; Craig D Ellermeier; David S Weiss
Journal:  Mol Microbiol       Date:  2018-10-14       Impact factor: 3.501

6.  Proline-dependent regulation of Clostridium difficile Stickland metabolism.

Authors:  Laurent Bouillaut; William T Self; Abraham L Sonenshein
Journal:  J Bacteriol       Date:  2012-12-07       Impact factor: 3.490

7.  Bacteriophage-mediated toxin gene regulation in Clostridium difficile.

Authors:  Revathi Govind; Govindsamy Vediyappan; Rial D Rolfe; Bruno Dupuy; Joe A Fralick
Journal:  J Virol       Date:  2009-09-23       Impact factor: 5.103

8.  The membrane as a target for controlling hypervirulent Clostridium difficile infections.

Authors:  Xiaoqian Wu; Philip T Cherian; Richard E Lee; Julian G Hurdle
Journal:  J Antimicrob Chemother       Date:  2012-12-21       Impact factor: 5.790

9.  Comparison of polymerase chain reaction ribotyping, toxinotyping and nutritional aspects of toxin production of Clostridium difficile strains.

Authors:  Shanshan Zhu; Liming Zhang; Chunling Zhang; Xianjun Chen; Qi Chen; Zhaoyun Li
Journal:  Biomed Rep       Date:  2014-04-25

10.  Expression of Clostridium difficile toxins A and B and their sigma factor TcdD is controlled by temperature.

Authors:  Sture Karlsson; Bruno Dupuy; Kakoli Mukherjee; Elisabeth Norin; Lars G Burman; Thomas Akerlund
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441
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