Literature DB >> 8282838

Antimicrobial activity of cytotoxic drugs may influence isolation of bacteria and fungi from blood cultures.

V Peiris1, B A Oppenheim.   

Abstract

The potential antimicrobial activity of cyclophosphamide, vincristine, and adriamycin against Gram positive and negative bacteria and Candida albicans was examined. The time taken for different microbial inocula to turn a simulated blood culture positive in the presence of different concentrations of these drugs was measured. Doxorubicin retarded the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus sanguis in a concentration dependent manner. Cyclophosphamide and vincristine showed minimal antimicrobial activity. Escherichia coli and Pseudomonas aeruginosa were unaffected by any of the drugs. An inoculum dependent effect was seen with some combinations of microbial inocula and cytotoxic drug concentrations.

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Year:  1993        PMID： 8282838      PMCID： PMC501725          DOI： 10.1136/jcp.46.12.1124

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  6 in total

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  7 in total

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