BACKGROUND: Because of the rarity of salivary gland cancer, little is known about the single-agent activity of most anticancer agents in the different histologic types of these cancers. PATIENTS AND METHODS: Twenty patients with advanced or recurrent adenoid cystic carcinoma of the head and neck were treated with epirubicin on a low-dose weekly schedule (30 mg/m2/week) for eight weeks and, in instances of no response, a high-dose three-weekly schedule (> or = 90 mg/m2). Thirteen patients had locoregional disease (12 recurrences), seven of them also had distant metastases and seven had distant metastases only. All had documented progressive disease, and 17 were symptomatic. RESULTS: Two objective responses of 7.5 and 20 months were observed in patients with locally recurrent disease, and ten patients showed disease stabilization. The median time to progression was 16 weeks (range 2-250 weeks) and the median survival 67 weeks (range 13-272+ weeks), with three patients still alive more than five years after the initiation of chemotherapy. Contrary to the rather modest objective response rate, symptomatic improvement occurred more frequently (29.4%) and was evident within 8 weeks of treatment. CONCLUSIONS: This type of chemotherapy should be reserved for patients with rapidly progressive disease or those with symptomatic disease.
BACKGROUND: Because of the rarity of salivary gland cancer, little is known about the single-agent activity of most anticancer agents in the different histologic types of these cancers. PATIENTS AND METHODS: Twenty patients with advanced or recurrent adenoid cystic carcinoma of the head and neck were treated with epirubicin on a low-dose weekly schedule (30 mg/m2/week) for eight weeks and, in instances of no response, a high-dose three-weekly schedule (> or = 90 mg/m2). Thirteen patients had locoregional disease (12 recurrences), seven of them also had distant metastases and seven had distant metastases only. All had documented progressive disease, and 17 were symptomatic. RESULTS: Two objective responses of 7.5 and 20 months were observed in patients with locally recurrent disease, and ten patients showed disease stabilization. The median time to progression was 16 weeks (range 2-250 weeks) and the median survival 67 weeks (range 13-272+ weeks), with three patients still alive more than five years after the initiation of chemotherapy. Contrary to the rather modest objective response rate, symptomatic improvement occurred more frequently (29.4%) and was evident within 8 weeks of treatment. CONCLUSIONS: This type of chemotherapy should be reserved for patients with rapidly progressive disease or those with symptomatic disease.
Authors: Afshin Teymoortash; Anna Pientka; Carsten Schrader; Markus Tiemann; Jochen A Werner Journal: J Cancer Res Clin Oncol Date: 2005-09-24 Impact factor: 4.553
Authors: Patrick M Dillon; Gina R Petroni; Bethany J Horton; Christopher A Moskaluk; Paula M Fracasso; Michael G Douvas; Nikole Varhegyi; Snjezana Zaja-Milatovic; Christopher Y Thomas Journal: Clin Cancer Res Date: 2017-04-04 Impact factor: 12.531
Authors: Athanassios Argiris; Musie Ghebremichael; Barbara Burtness; Rita S Axelrod; Ronald C Deconti; Arlene A Forastiere Journal: Cancer Date: 2011-01-18 Impact factor: 6.860
Authors: Laura Vidal; Ming S Tsao; Gregory R Pond; Ezra E W Cohen; Roger B Cohen; Eric X Chen; Mark Agulnik; Sebastien Hotte; Eric Winquist; Scott Laurie; D Neil Hayes; James Ho; Janet Dancey; Lillian L Siu Journal: Head Neck Date: 2009-08 Impact factor: 3.147
Authors: Moses Tam; Nadeem Riaz; Lucas Resende Salgado; Daniel E Spratt; Evangelia Katsoulakis; Alan Ho; Luc G T Morris; Richard Wong; Suzanne Wolden; Shyam Rao; Nancy Lee Journal: J Radiat Oncol Date: 2013-07-10