Literature DB >> 827778

The inhibitory effect of intraventricular administration of serotonin on spontaneous motor activity of rats.

R A Green, J C Gillin, R J Wyatt.   

Abstract

Spontaneous motor activity was studied following injection of 1, 10 and 50 mug of serotonin (5-HT) into the lateral ventricle of chronically cannulated rats. During the first 15 min, the rats receiving the higher doses of 5-HT showed significant decrements (P less than 0.01) in motor activity compared to saline controls. No activation was observed in either group. After 20 min, no significant differences for any treatment condition compared to saline controls were observed. It is concluded that a principal effect of directly increasing brain 5-HT concentration is to decrease activity. Possible mechanisms for this effect are discussed.

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Year:  1976        PMID： 827778     DOI： 10.1007/BF00426326

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  18 in total

1.  Cellular localization of monoamines in the area postrema of certain mammals.

Authors:  K Fuxe; C Owman
Journal:  J Comp Neurol       Date:  1965-12       Impact factor: 3.215

2.  Influence of drugs on the firing of serotonin-containing neurons in brain.

Authors:  G K Aghajanian
Journal:  Fed Proc       Date:  1972 Jan-Feb

Review 3.  Biogenic amines and the states of sleep.

Authors:  M Jouvet
Journal:  Science       Date:  1969-01-03       Impact factor: 47.728

4.  Effects of para-chlorophenylalanine on sleep in man.

Authors:  R J Wyatt; K Engelman; D J Kupfer; J Scott; A Sjoerdsma; F Snyder
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1969-11

5.  p-Chlorophenylalanine: a specific depletor of brain serotonin.

Authors:  B K Koe; A Weissman
Journal:  J Pharmacol Exp Ther       Date:  1966-12       Impact factor: 4.030

6.  Excitatory effects of 5-HTP on intracranial self-stimulation following MAO blockade.

Authors:  B P Poschel; F W Ninteman
Journal:  Life Sci       Date:  1968-03-01       Impact factor: 5.037

7.  Effects of L-tryptophan (a natural sedative) on human sleep.

Authors:  R J Wyatt; K Engelman; D J Kupfer; D H Fram; A Sjoerdsma; F Snyder
Journal:  Lancet       Date:  1970-10-24       Impact factor: 79.321

Review 8.  What is the functional role of central nervous serotonin?

Authors:  W P Koella
Journal:  Neurosci Res (N Y)       Date:  1969

9.  Mechanism of the EEG-synchronizing action of serotonin.

Authors:  W P Koella; J Czicman
Journal:  Am J Physiol       Date:  1966-10

10.  Serotonin-containing neurons in brain: depression of firing by monoamine oxidase inhibitors.

Authors:  G K Aghajanian; A W Graham; M H Sheard
Journal:  Science       Date:  1970-09-11       Impact factor: 47.728
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  5 in total

1.  The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor activity.

Authors:  J J Feigenbaum; J Yanai; H L Klawans
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

2.  The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced locomotor activity.

Authors:  J J Feigenbaum; J Yanai; H L Klawans
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

3.  Mediation of central prostaglandin effects by serotoninergic neurons.

Authors:  R Brus; Z S Herman; R Szkilnik; J Zabawska
Journal:  Psychopharmacology (Berl)       Date:  1979-06-28       Impact factor: 4.530

4.  Interaction of dietary tryptophan and social isolation on territorial aggression, motor activity, and neurochemistry in mice.

Authors:  S M Lasley; J B Thurmond
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

5.  5-Hydroxytryptamine involvement in the locomotor activity suppressant effects of amphetamine in the mouse.

Authors:  A J Bradbury; B Costall; R J Naylor; E S Onaivi
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  5 in total

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