Literature DB >> 827769

A comparison of the central actions of prostaglandins A1, E1, E2, F1alpha, and F2alpha in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat.

Z M Poddubiuk.   

Abstract

The effect of prostaglandins (PGs) A1, E1, E2, F1alpha, and F2alpha administered intraventricularly at doses of 0.02--4.0 mug/rat were studied in some behavioral, antinociceptive and anticonvulsant tests in rats. Exploratory and locomotor activity were decreased by all PGs except A1 and F2alpha which had no effect on locomotor activity. All PGs studied, except A1, induced hyperthermia and afforded protection in the 'hot-plate' analgesic test and against maximal electro-shock seizures.

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Year:  1976        PMID： 827769     DOI： 10.1007/BF00634161

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  28 in total

1.  EFFECTS ON TEMPERATURE OF AMINES INJECTED INTO THE CEREBRAL VENTRICLES. A NEW CONCEPT OF TEMPERATURE REGULATION.

Authors:  W FELDBERG; R D MYERS
Journal:  J Physiol       Date:  1964-09       Impact factor: 5.182

2.  ISOLATION AND IDENTIFICATION OF PROSTAGLANDINS FROM HUMAN SEMINAL PLASMA. 18. PROSTAGLANDINS AND RELATED FACTORS.

Authors:  B SAMUELSSON
Journal:  J Biol Chem       Date:  1963-10       Impact factor: 5.157

3.  Properties of maximal seizures, and their alteration by anticonvulant drugs and other agents.

Authors:  J E P TOMAN; E A SWINYARD; L S GOODMAN
Journal:  J Neurophysiol       Date:  1946-05       Impact factor: 2.714

4.  Central effects of prostaglandin E1 in adult fowls.

Authors:  G Nisticò; E Marley
Journal:  Neuropharmacology       Date:  1973-11       Impact factor: 5.250

5.  Effects of prostaglandin E 2 on the body temperature of conscious rats and cats.

Authors:  W J Potts; P F East
Journal:  Arch Int Pharmacodyn Ther       Date:  1972-05

6.  Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats.

Authors:  P W Ramwell; J E Shaw
Journal:  Am J Physiol       Date:  1966-07

7.  Actions of prostaglandins E1, E2, and F2-alpha on brain stem neurones.

Authors:  G L Avanzino; P B Bradley; J H Wolstencroft
Journal:  Br J Pharmacol Chemother       Date:  1966-05

8.  ACTIONS OF PROSTAGLANDINS E1, E2 AND E3 ON THE CENTRAL NERVOUS SYSTEM.

Authors:  E W HORTON
Journal:  Br J Pharmacol Chemother       Date:  1964-02

9.  Further observations on the central nervous actions of prostaglandins F2a and E1. With an addendum on the effects of prostglandins E1 and F2a on systemic arterial blood pressure in chicks.

Authors:  E W Horton; I H Main
Journal:  Br J Pharmacol Chemother       Date:  1967-08

10.  Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits.

Authors:  A S Milton; S Wendlandt
Journal:  J Physiol       Date:  1971-10       Impact factor: 5.182
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  10 in total

1.  Prostaglandins and the central nervous system.

Authors:  E Marley; S Poole; J D Stephenson
Journal:  Postgrad Med J       Date:  1977-11       Impact factor: 2.401

2.  Effect of low intake of n-3 fatty acids during development on brain phospholipid fatty acid composition and exploratory behavior in rats.

Authors:  M Enslen; H Milon; A Malnoë
Journal:  Lipids       Date:  1991-03       Impact factor: 1.880

3.  Influence of polyphloretin phosphate on the central effects of prostaglandin E2 and F2alpha in rats.

Authors:  R Brus; Z S Herman; R Szkilnik; J Słominska-Zurek; J Zabawska; Z Jamrozik; A Kryk
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

4.  Mediation of central prostaglandin effects by serotoninergic neurons.

Authors:  R Brus; Z S Herman; R Szkilnik; J Zabawska
Journal:  Psychopharmacology (Berl)       Date:  1979-06-28       Impact factor: 4.530

5.  Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha.

Authors:  U Förstermann; R Heldt; G Hertting
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

6.  Protective effect of prostaglandins D2, E1 and I2 against cerebral hypoxia/anoxia in mice.

Authors:  Y Masuda; Y Ochi; Y Ochi; T Karasawa; N Hatano; T Kadokawa; M Shimizu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000

7.  Alteration in the level of endogenous hypothalamic prostaglandins induced by delta 9-tetrahydrocannabinol in the rat.

Authors:  I M Coupar; D A Taylor
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

8.  Sedation produced by prostaglandins is not a nonspecific fatty acid effect.

Authors:  E B Holingsworth; G A Patrick
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

9.  Prostaglandin inhibition of amphetamine-induced circling in mice.

Authors:  R D Schwarz; N J Uretsky; J R Bianchine
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

10.  A comparison of the central actions of prostaglandins A1, E1, E2, F1alpha, and F2alpha in the rat. II. The effect of intraventricular prostaglandins on the action of some drugs and on the level and turnover of biogenic amines in the rat brain.

Authors:  Z M Poddubiuk; Z Kleinrok
Journal:  Psychopharmacology (Berl)       Date:  1976-10-20       Impact factor: 4.530
  10 in total

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