Literature DB >> 14126050

ACTIONS OF PROSTAGLANDINS E1, E2 AND E3 ON THE CENTRAL NERVOUS SYSTEM.

E W HORTON.   

Abstract

Prostaglandins E(1), E(2) and E(3), injected into the cerebral ventricles of unanaesthetized cats, produced sedation, stupor and signs of catatonia. The threshold dose was 3 mug/kg. Slight sedation was also observed following an intravenous injection, but a dose of 20 mug/kg was required. In chicks, intravenous injections of prostaglandins (10 to 400 mug/kg) caused respiratory depression, profound sedation, loss of normal posture and, with the higher doses, loss of the righting reflex.

Entities:  

Keywords:  BIOLOGICAL PRODUCTS; BRAIN; CATATONIA; CATS; CEREBRAL VENTRICLES; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; POULTRY; PROSTAGLANDINS; TISSUE EXTRACTS

Mesh：

Substances：

Year:  1964        PMID： 14126050      PMCID： PMC1703918          DOI： 10.1111/j.1476-5381.1964.tb01558.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  6 in total

1.  Biologically active substances in brain extracts.

Authors:  C C TOH
Journal:  J Physiol       Date:  1963-01       Impact factor: 5.182

2.  [Pharmacologically active lipidsoluble acids in brain extracts: isolation of lysophosphatidic acid and ganglioside].

Authors:  H KIRSCHNER; W VOGT
Journal:  Biochem Pharmacol       Date:  1961-09       Impact factor: 5.858

3.  Injections of bulbocapnine into the cerebral ventricles of cats.

Authors:  W FELDBERG; S L SHERWOOD
Journal:  Br J Pharmacol Chemother       Date:  1955-09

4.  Behaviour of cats after intraventricular injections of eserine and DFP.

Authors:  W FELDBERG; S L SHERWOOD
Journal:  J Physiol       Date:  1954-09-28       Impact factor: 5.182

5.  THE EFFECT OF PROSTAGLANDIN E1 ON RESPONSES OF SMOOTH MUSCLE TO CATECHOL AMINES, ANGIOTENSIN AND VASOPRESSIN.

Authors:  S W HOLMES; E W HORTON; I H MAIN
Journal:  Br J Pharmacol Chemother       Date:  1963-12

6.  A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS.

Authors:  E W HORTON; I H MAIN
Journal:  Br J Pharmacol Chemother       Date:  1963-08
  6 in total
  39 in total

1.  A COMPARISON OF THE ACTIONS OF PROSTAGLANDINS F2-ALPHA AND E1 ON SMOOTH MUSCLE.

Authors:  E W HORTON; I H MAIN
Journal:  Br J Pharmacol Chemother       Date:  1965-04

2.  Anorectic activity of prostaglandin precursors.

Authors:  N S Doggett; K Jawaharlal
Journal:  Br J Pharmacol       Date:  1977-07       Impact factor: 8.739

3.  Some observations on the anorectic activity of prostaglandin F2alpha.

Authors:  N S Doggett; K Jawaharlal
Journal:  Br J Pharmacol       Date:  1977-07       Impact factor: 8.739

4.  The distribution of tritium-labelled prostaglandin E(1) injected in amounts sufficient to produce central nervous effects in cats and chicks.

Authors:  S W Holmes; E W Horton
Journal:  Br J Pharmacol       Date:  1968-09       Impact factor: 8.739

5.  Correlation of prostaglandin release from the cerebral cortex of cats with the electrocorticogram, following stimulation of the reticular formation.

Authors:  P B Bradley; G M Samuels; J E Shaw
Journal:  Br J Pharmacol       Date:  1969-09       Impact factor: 8.739

6.  A comparison of the central actions of prostaglandins A1, E1, E2, F1alpha, and F2alpha in the rat. I. Behavioral, antinociceptive and anticonvulsant actions of intraventricular prostaglandins in the rat.

Authors:  Z M Poddubiuk
Journal:  Psychopharmacology (Berl)       Date:  1976-10-20       Impact factor: 4.530

7.  The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.

Authors:  H B Steinhauer; H Anhut; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

8.  Prostaglandin E1 causes sedation and increases 5-hydroxytryptamine turnover in rat brain.

Authors:  D R Haubrich; J Perez-Cruet; W D Reid
Journal:  Br J Pharmacol       Date:  1973-05       Impact factor: 8.739

9.  The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release.

Authors:  S W Holmes
Journal:  Br J Pharmacol       Date:  1970-04       Impact factor: 8.739

10.  Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha.

Authors:  U Förstermann; R Heldt; G Hertting
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.