Literature DB >> 8277291

Characterization of vaccinia virus gene B12R.

A H Banham1, G L Smith.   

Abstract

We report the characterization of vaccinia virus gene B12R which is predicted to encode a 33K protein with 36% amino acid identity to the serine/threonine protein kinase encoded by vaccinia virus gene B1R. S1 nuclease protection experiments showed that gene B12R is transcribed early during infection from an initiation site 11 bp upstream of the open reading frame (ORF). The gene encodes a 33K polypeptide that is not required for virus replication in tissue culture nor for virus virulence in a murine intranasal model. Expression of the B12R gene in Escherichia coli produced an abundant 33K polypeptide which lacked protein kinase activity under conditions in which the protein kinases encoded by vaccinia virus gene B1R and African swine fever virus gene j9L are active.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8277291     DOI： 10.1099/0022-1317-74-12-2807

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  11 in total

1.  Role of genes that modulate host immune responses in the immunogenicity and pathogenicity of vaccinia virus.

Authors:  Shawn S Jackson; Petr Ilyinskii; Valérie Philippon; Linda Gritz; Alicia Gómez Yafal; Kimberly Zinnack; Kristin R Beaudry; Kelledy H Manson; Michelle A Lifton; Marcelo J Kuroda; Norman L Letvin; Gail P Mazzara; Dennis L Panicali
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

2.  The Vaccinia Virus (VACV) B1 and Cellular VRK2 Kinases Promote VACV Replication Factory Formation through Phosphorylation-Dependent Inhibition of VACV B12.

Authors:  Amber B Rico; Zhigang Wang; Annabel T Olson; Alexandria C Linville; Brianna L Bullard; Eric A Weaver; Clinton Jones; Matthew S Wiebe
Journal:  J Virol       Date:  2019-09-30       Impact factor: 5.103

3.  Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve Immunogenicity.

Authors:  Naif Khalaf Alharbi; Alexandra J Spencer; Adrian V S Hill; Sarah C Gilbert
Journal:  PLoS One       Date:  2015-06-08       Impact factor: 3.240

4.  Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.

Authors:  Tracy J Yuen; Inge E A Flesch; Natasha A Hollett; Bianca M Dobson; Tiffany A Russell; Aude M Fahrer; David C Tscharke
Journal:  J Virol       Date:  2010-07-28       Impact factor: 5.103

Review 5.  Monkeypox virus and insights into its immunomodulatory proteins.

Authors:  Jessica R Weaver; Stuart N Isaacs
Journal:  Immunol Rev       Date:  2008-10       Impact factor: 12.988

6.  The Vaccinia Virus B12 Pseudokinase Represses Viral Replication via Interaction with the Cellular Kinase VRK1 and Activation of the Antiviral Effector BAF.

Authors:  Amber B Rico; Alexandria C Linville; Annabel T Olson; Zhigang Wang; Matthew S Wiebe
Journal:  J Virol       Date:  2021-01-13       Impact factor: 5.103

Review 7.  Functional organization of variola major and vaccinia virus genomes.

Authors:  S N Shchelkunov
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

8.  Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase.

Authors:  Alexandria C Linville; Amber B Rico; Helena Teague; Lucy E Binsted; Geoffrey L Smith; Jonas D Albarnaz; Matthew S Wiebe
Journal:  J Virol       Date:  2022-05-11       Impact factor: 6.549

9.  Attenuation of monkeypox virus by deletion of genomic regions.

Authors:  Juan G Lopera; Elizabeth A Falendysz; Tonie E Rocke; Jorge E Osorio
Journal:  Virology       Date:  2014-12-01       Impact factor: 3.616

10.  A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase.

Authors:  Annabel T Olson; Zhigang Wang; Amber B Rico; Matthew S Wiebe
Journal:  PLoS Pathog       Date:  2019-02-15       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.