J A Ship1, S A Puckett. 1. Department of Oral Medicine, Pathology, and Surgery, University of Michigan School of Dentistry, Ann Arbor 48109-1078.
Abstract
OBJECTIVE: To examine longitudinal oral health changes in unmedicated, generally healthy subjects with Alzheimer's disease (AD) and compare them to age- and gender-matched healthy, unmedicated control subjects. DESIGN: Oral health parameters were evaluated over 2 to 3 years and the results compared between subjects with AD and controls. SETTING: Clinical Center of the National Institutes of Health, Bethesda, Maryland. PARTICIPANTS: Twenty-one community-dwelling subjects with a clinical diagnosis of AD and 21 age- and gender-matched control subjects. Neither population was being treated for any other systemic condition nor taking any prescription medications. MEASUREMENTS: Unstimulated and stimulated major salivary gland flow rates were measured, and gingival, periodontal, dental, and oral mucosal tissues assessed. MAIN RESULTS: In general, subjects with AD demonstrated decreased salivary flow rates and diminished oral health, but most longitudinal changes in oral health status were not significantly different than controls. CONCLUSIONS: Patients with AD are susceptible to a variety of oral health problems, and progression of AD can lead to a deterioration in oral health and function. These patients require aggressive preventive care to maintain function for as long as possible, which necessitates close cooperation among numerous health care professionals.
OBJECTIVE: To examine longitudinal oral health changes in unmedicated, generally healthy subjects with Alzheimer's disease (AD) and compare them to age- and gender-matched healthy, unmedicated control subjects. DESIGN: Oral health parameters were evaluated over 2 to 3 years and the results compared between subjects with AD and controls. SETTING: Clinical Center of the National Institutes of Health, Bethesda, Maryland. PARTICIPANTS: Twenty-one community-dwelling subjects with a clinical diagnosis of AD and 21 age- and gender-matched control subjects. Neither population was being treated for any other systemic condition nor taking any prescription medications. MEASUREMENTS: Unstimulated and stimulated major salivary gland flow rates were measured, and gingival, periodontal, dental, and oral mucosal tissues assessed. MAIN RESULTS: In general, subjects with AD demonstrated decreased salivary flow rates and diminished oral health, but most longitudinal changes in oral health status were not significantly different than controls. CONCLUSIONS:Patients with AD are susceptible to a variety of oral health problems, and progression of AD can lead to a deterioration in oral health and function. These patients require aggressive preventive care to maintain function for as long as possible, which necessitates close cooperation among numerous health care professionals.
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