Literature DB >> 8274548

Optimization by hierarchical mutant production.

A Schober1, M Thuerk, M Eigen.   

Abstract

Inspired by the successful description of the first steps of molecular evolution by the quasispecies theory and the successful application of quasispecies-like algorithms to optimization problems, we propose a hierarchically organized algorithm. This new algorithm is able to solve a spin glass and a travelling salesman problem using only point mutations. Furthermore, it performs better under comparable circumstances than the ordinary quasispecies algorithm. Depending on the structure of the fitness landscape of the examined problem under consideration the hierarchically organized algorithm proves to be much more suitable than a simple quasispecies algorithm, especially in clustered landscapes. Tuning the error rates reveals the critical minimum copy fidelity necessary to guarantee optimization. We propose to incorporate hierarchical concepts into optimization algorithms inspired by biological evolution, such a genetic algorithms.

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Year:  1993        PMID: 8274548

Source DB:  PubMed          Journal:  Biol Cybern        ISSN: 0340-1200            Impact factor:   2.086


  12 in total

1.  Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet.

Authors:  M Nowak; P Schuster
Journal:  J Theor Biol       Date:  1989-04-20       Impact factor: 2.691

2.  Optimization by simulated annealing.

Authors:  S Kirkpatrick; C D Gelatt; M P Vecchi
Journal:  Science       Date:  1983-05-13       Impact factor: 47.728

3.  Kinetics of RNA replication: competition and selection among self-replicating RNA species.

Authors:  C K Biebricher; M Eigen; W C Gardiner
Journal:  Biochemistry       Date:  1985-11-05       Impact factor: 3.162

4.  Why some fitness landscapes are fractal.

Authors:  E D Weinberger; P F Stadler
Journal:  J Theor Biol       Date:  1993-07-21       Impact factor: 2.691

5.  Physical aspects of evolutionary optimization and adaptation.

Authors: 
Journal:  Phys Rev A Gen Phys       Date:  1989-09-15

6.  Self-organization in prebiological systems: simulations of a model for the origin of genetic information.

Authors:  D S Rokhsar; P W Anderson; D L Stein
Journal:  J Mol Evol       Date:  1986       Impact factor: 2.395

7.  Handicapped individua in evolutionary processes.

Authors:  R Galar
Journal:  Biol Cybern       Date:  1985       Impact factor: 2.086

8.  Optimization by stimulating molecular evolution.

Authors:  Q H Wang
Journal:  Biol Cybern       Date:  1987       Impact factor: 2.086

9.  Kinetics of RNA replication: plus-minus asymmetry and double-strand formation.

Authors:  C K Biebricher; M Eigen; W C Gardiner
Journal:  Biochemistry       Date:  1984-07-03       Impact factor: 3.162

10.  Kinetics of RNA replication.

Authors:  C K Biebricher; M Eigen; W C Gardiner
Journal:  Biochemistry       Date:  1983-05-10       Impact factor: 3.162

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