Literature DB >> 3620547

Optimization by stimulating molecular evolution.

Q H Wang.   

Abstract

Based on the analogy between mathematical optimization and molecular evolution and on Eigen's quasi-species model of molecular evolution, an evolutionary algorithm for combinatorial optimization has been developed. This algorithm consists of a versatile variation scheme and an innovative decision rule, the essence of which lies in a radical revision of the conventional philosophy of optimization: A number of configurations of variables with better values, instead of only a single best configuration, are selected as starting points for the next iteration. As a result the search proceeds in parallel along a number of routes and is unlikely to get trapped in local optima. An important innovation of the algorithm is introduction of a constraint to let the starting points always keep a certain distance from each other so that the search is able to cover a larger region of space effectively. The main advantage of the algorithm is that it has more chances to find the global optimum and as many local optima as possible in a single run. This has been demonstrated in preliminary computational experiments.

Mesh:

Year:  1987        PMID: 3620547     DOI: 10.1007/bf00318719

Source DB:  PubMed          Journal:  Biol Cybern        ISSN: 0340-1200            Impact factor:   2.086


  10 in total

1.  Optimization by simulated annealing.

Authors:  S Kirkpatrick; C D Gelatt; M P Vecchi
Journal:  Science       Date:  1983-05-13       Impact factor: 47.728

2.  Evolution in vitro: sequence and phenotype of a mutant RNA resistant to ethidium bromide.

Authors:  F R Kramer; D R Mills; P E Cole; T Nishihara; S Spiegelman
Journal:  J Mol Biol       Date:  1974-11-15       Impact factor: 5.469

3.  An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.

Authors:  D R Mills; R L Peterson; S Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1967-07       Impact factor: 11.205

4.  Kinetic analysis of template-instructed and de novo RNA synthesis by Q beta replicase.

Authors:  C K Biebricher; M Eigen; R Luce
Journal:  J Mol Biol       Date:  1981-06-05       Impact factor: 5.469

5.  Neural networks and physical systems with emergent collective computational abilities.

Authors:  J J Hopfield
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

6.  Product analysis of RNA generated de novo by Q beta replicase.

Authors:  C K Biebricher; M Eigen; R Luce
Journal:  J Mol Biol       Date:  1981-06-05       Impact factor: 5.469

Review 7.  Selforganization of matter and the evolution of biological macromolecules.

Authors:  M Eigen
Journal:  Naturwissenschaften       Date:  1971-10

8.  The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.

Authors:  M Eigen; P Schuster
Journal:  Naturwissenschaften       Date:  1977-11

9.  Evidence for de novo production of self-replicating and environmentally adapted RNA structures by bacteriophage Qbeta replicase.

Authors:  M Sumper; R Luce
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

  10 in total
  2 in total

1.  RNA based evolutionary optimization.

Authors:  P Schuster
Journal:  Orig Life Evol Biosph       Date:  1993-12       Impact factor: 1.950

2.  Optimization by hierarchical mutant production.

Authors:  A Schober; M Thuerk; M Eigen
Journal:  Biol Cybern       Date:  1993       Impact factor: 2.086

  2 in total

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