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Literature DB >> 8273589

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level.

P Young¹, P McDonnell, D Dunnington, A Hand, J Laydon, J Lee.

Abstract

The mechanism by which SK&F 86002 and other pyridinyl imidazoles inhibit the production of IL-1 and TNF from LPS-stimulated human monocytes was examined. Inhibition of IL-1 and TNF production was found to depend on the time of addition of SK&F 86002, with diminishing effect when added more than 2 h after LPS stimulation. Analysis of Western blots confirmed that both intracellular IL-1 beta and extracellular TNF were significantly reduced in response to SK&F 86002, but these reductions were not paralleled by changes in IL-1 and TNF mRNA. 35S methionine pulse and pulse-chase studies on IL-1 biosynthesis suggest that significant inhibition by SK&F 86002 and related compounds occurs at the translational level.

Entities: Chemical Gene Species

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Year: 1993 PMID： 8273589 DOI： 10.1007/bf01972723

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

7 in total

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