Literature DB >> 8273583

Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots.

I G Butenko1, S V Gladtchenko, S V Galushko.   

Abstract

Anti-inflammatory activity of baicalein (5,6,7-trioxyflavone-7-O-beta-D-glucuronide) was greater in the chronic inflammation model (rat adjuvant arthritis, ED50 = 120.6 mg/kg) than observed in the rat carrageenan-induced paw edema, ED50 > or = 200.0 mg/kg. A comparative study of the 5-lipoxygenase (5-LO) inhibitory activity of baicalein, BW 755 C, and hydroxamic acid arachidonate on leukotriene C4 (LTC4) biosynthesis by rat resident peritoneal macrophages stimulated with calcium ionophore (A 23186) showed that these drugs significantly inhibited LTC4 production, IC50: 9.5, 41.8, and 2.8 microM, respectively. This finding suggests that inhibition of the 5-LO pathway of arachidonic acid metabolism may be one of the mechanisms of baicalein's anti-inflammatory activity.

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Year:  1993        PMID： 8273583     DOI： 10.1007/bf01972717

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

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Journal:  Proc Soc Exp Biol Med       Date:  1962-12

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Authors:  C M PEARSON
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

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Review 4.  Control mechanisms of mediator release in human basophils and mast cells.

Authors:  G Marone
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5.  Influences of salts on high-performance liquid chromatography of leukotrienes.

Authors:  M Abe; Y Kawazoe; N Shigematsu
Journal:  Anal Biochem       Date:  1985-02-01       Impact factor: 3.365

6.  Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids.

Authors:  M L Ferrándiz; M J Alcaraz
Journal:  Agents Actions       Date:  1991-03

7.  Macrophage activation in rat models of inflammation and arthritis. Systemic activation precedes arthritis induction and progression.

Authors:  W J Johnson; K A Muirhead; P C Meunier; B J Votta; T C Schmitt; M J DiMartino; N Hanna
Journal:  Arthritis Rheum       Date:  1986-09
  7 in total
  6 in total

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Journal:  Molecules       Date:  2020-10-22       Impact factor: 4.411

6.  Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing.

Authors:  Ibrahim Mssillou; Abdelkrim Agour; Meryem Slighoua; Mohamed Chebaibi; Fatima Ez-Zahra Amrati; Samar Zuhair Alshawwa; Omkulthom Al Kamaly; Abdelfattah El Moussaoui; Badiaa Lyoussi; Elhoussine Derwich
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-25
  6 in total

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