| Literature DB >> 8272873 |
N Stahl1, T G Boulton, T Farruggella, N Y Ip, S Davis, B A Witthuhn, F W Quelle, O Silvennoinen, G Barbieri, S Pellegrini.
Abstract
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.Entities:
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Year: 1994 PMID： 8272873 DOI： 10.1126/science.8272873
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728