Literature DB >> 12587663

Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS.

P Dell'Albani1, R Santangelo, L Torrisi, V G Nicoletti, A M Giuffrida Stella.   

Abstract

Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).

Mesh：

Substances：

Year:  2003        PMID： 12587663     DOI： 10.1023/a:1021644027850

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  91 in total

1.  Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis.

Authors:  M A Aberg; F Ryttsén; G Hellgren; K Lindell; L E Rosengren; A J MacLennan; B Carlsson; O Orwar; P S Eriksson
Journal:  Mol Cell Neurosci       Date:  2001-03       Impact factor: 4.314

2.  Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

Authors:  E Galea; D L Feinstein; D J Reis
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

Review 3.  STATs: signal transducers and activators of transcription.

Authors:  J N Ihle
Journal:  Cell       Date:  1996-02-09       Impact factor: 41.582

4.  Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.

Authors:  S J Frank; G Gilliland; A S Kraft; C S Arnold
Journal:  Endocrinology       Date:  1994-11       Impact factor: 4.736

5.  Stat5a is mandatory for adult mammary gland development and lactogenesis.

Authors:  X Liu; G W Robinson; K U Wagner; L Garrett; A Wynshaw-Boris; L Hennighausen
Journal:  Genes Dev       Date:  1997-01-15       Impact factor: 11.361

6.  Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.

Authors:  M Zhu; S John; M Berg; W J Leonard
Journal:  Cell       Date:  1999-01-08       Impact factor: 41.582

7.  Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

Authors:  C Lütticken; U M Wegenka; J Yuan; J Buschmann; C Schindler; A Ziemiecki; A G Harpur; A F Wilks; K Yasukawa; T Taga
Journal:  Science       Date:  1994-01-07       Impact factor: 47.728

8.  Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

Authors:  D K Dalton; S Pitts-Meek; S Keshav; I S Figari; A Bradley; T A Stewart
Journal:  Science       Date:  1993-03-19       Impact factor: 47.728

9.  Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages.

Authors:  Y G Yeung; Y Wang; D B Einstein; P S Lee; E R Stanley
Journal:  J Biol Chem       Date:  1998-07-03       Impact factor: 5.157

10.  bcl-2 inhibits death of central neural cells induced by multiple agents.

Authors:  L T Zhong; T Sarafian; D J Kane; A C Charles; S P Mah; R H Edwards; D E Bredesen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205
View more
  9 in total

1.  Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells.

Authors:  Kumiko Tanabe; Rie Matsushima-Nishiwaki; Shinobu Yamaguchi; Hiroki Iida; Shuji Dohi; Osamu Kozawa
Journal:  J Neuroinflammation       Date:  2010-03-06       Impact factor: 8.322

2.  Caveolae Microdomains Mediate STAT5 Signaling Induced by Insulin in MCF-7 Breast Cancer Cells.

Authors:  Rocio Castillo-Sanchez; Pedro Cortes-Reynosa; Mario Lopez-Perez; Alejandra Garcia-Hernandez; Eduardo Perez Salazar
Journal:  J Membr Biol       Date:  2022-06-25       Impact factor: 1.843

3.  The antihypertension drug doxazosin suppresses JAK/STATs phosphorylation and enhances the effects of IFN-α/γ-induced apoptosis.

Authors:  Mi Sun Park; Boh-Ram Kim; Sokbom Kang; Dae-Yong Kim; Seung Bae Rho
Journal:  Genes Cancer       Date:  2014-11

4.  The use of protein-DNA, chromatin immunoprecipitation, and transcriptome arrays to describe transcriptional circuits in the dehydrated male rat hypothalamus.

Authors:  Jing Qiu; Anna Kleineidam; Sabine Gouraud; Song Tieng Yao; Mingkwan Greenwood; See Ziau Hoe; Charles Hindmarch; David Murphy
Journal:  Endocrinology       Date:  2014-08-21       Impact factor: 4.736

Review 5.  Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets-A Focus on the JAK-STAT Pathway.

Authors:  Fausto Salaffi; Giovanni Giacobazzi; Marco Di Carlo
Journal:  Pain Res Manag       Date:  2018-02-07       Impact factor: 3.037

6.  B14 ameliorates bone cancer pain through downregulating spinal interleukin-1β via suppressing neuron JAK2/STAT3 pathway.

Authors:  Miao Xu; Huadong Ni; Longsheng Xu; Hui Shen; Housheng Deng; Yungong Wang; Ming Yao
Journal:  Mol Pain       Date:  2019 Jan-Dec       Impact factor: 3.395

7.  Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice.

Authors:  Han-Chung Lee; Hamizun Hamzah; Pike-See Cheah; King-Hwa Ling; Melody Pui-Yee Leong; Hadri Md Yusof; Omar Habib; Shahidee Zainal Abidin; Eryse Amira Seth; Siong-Meng Lim; Sharmili Vidyadaran; Mohamad Aris Mohd Moklas; Maizaton Atmadini Abdullah; Norshariza Nordin; Zurina Hassan
Journal:  Sci Rep       Date:  2021-02-15       Impact factor: 4.379

8.  Retracted Article: Gm5820, an antisense RNA of FGF1, suppresses FGF1 expression at the posttranscriptional level to inactivate the ERK/STAT3 pathway and alleviates neuropathic pain in mice.

Authors:  Xin Zhang; Qing Yang; Tao Ding; Jingyu Xu; Zeng Yan; Yanhua Men; Wenqi Xin; Haixia Xu
Journal:  RSC Adv       Date:  2019-09-09       Impact factor: 4.036

Review 9.  Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain.

Authors:  Han-Chung Lee; Kai-Leng Tan; Pike-See Cheah; King-Hwa Ling
Journal:  Neural Plast       Date:  2016-01-12       Impact factor: 3.599
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.