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Literature DB >> 8270252

Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient.

J Cozzi¹, E Chevret, S Rousseaux, R Pelletier, V Benitz, H Jalbert, B Sèle.

Abstract

Human sperm chromosomes from a 46,XY/47,XXY male were obtained using the technique of in vitro penetration of zona-free hamster eggs. The analysis of 543 sperm complements shows a significantly increased incidence (0.9%) of hyperhaploid gonosomal 24,XY sets, with a lack of the expected corresponding gonosomal hypohaploidies, and a normal rate of autosomal non-disjunctions. These results support the suggestion that 47,XXY cells are able to go through meiosis and to form spermatozoa. Only 24,XY sperm chromosomal constitutions were observed suggesting a preferential pairing of homologous sex chromosomes in 47,XXY spermatocytes.

Entities: Species

Mesh：

Year: 1994 PMID： 8270252 DOI： 10.1007/bf00218909

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

22 in total

5. Setting Up a Cryopreservation Programme for Immature Testicular Tissue: Lessons Learned After More Than 15 Years of Experience.

Authors: Aude Braye; Herman Tournaye; Ellen Goossens
Journal: Clin Med Insights Reprod Health Date: 2019-11-20

5 in total

Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient.

1. Meiotic and sperm chromosome analysis in a male carrier of an inverted insertion (3;10)(q13.2;p14p13).

2. Distribution of aneuploidy in human gametes: comparison between human sperm and oocytes.

3. XY spermatocytes in an XYY male.

4. [Study of meiotic chromosomes in a caseof Klinefelter'sdisease with spermatogenesis and 46,XY-47,XXY karyotype].

5. Fluorescent evidence for spermatocytes with two Y chromosomes in an XYY male.

6. [Incidence of chromosome abnormalities in male sterility. Apropos of 40 cases].

7. Association between the degree of mosaicism and the severity of syndrome in Turner mosaics and Klinefelter mosaics.

8. Synaptonemal complex studies in a mosaic 46,XY/47,XXY male.

9. Chromosomes of human sperm: variability among normal individuals.

10. Sperm chromosome complements from two human reciprocal translocation heterozygotes.

Review 1. Genetically determined male infertility and assisted reproduction techniques.

2. Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization.

3. Increased incidence of hyperhaploid 24,XY spermatozoa detected by three-colour FISH in a 46,XY/47,XXY male.

4. Is genetic fatherhood within reach for all azoospermic Klinefelter men?

5. Setting Up a Cryopreservation Programme for Immature Testicular Tissue: Lessons Learned After More Than 15 Years of Experience.