Laparoscopic vs. open wedge biopsy of the liver.

This study was a post-hoc evaluation of laparoscopic versus open wedge biopsy of the liver performed as part of prospective phase I antibiotic trial. Consenting patients undergoing elective cholecystectomy were enrolled in a protocol which required samples of bile, blood, the gallbladder, and 1 gram of liver tissue. The study occurred during the evolution of laparoscopic surgery. Liver biopsy was done in standard fashion and laparoscopic liver biopsy was accomplished with cauterized scissors. Twenty-four patients, 4 male and 20 female averaging 42.1 years of age, were entered in this study. Eighteen patients underwent laparoscopic surgery and six patients underwent open surgery. They did not differ significantly in age (43.9 vs 42.1 years), operating room time (58.3 min vs 55.8 min), or complications (2/18 vs 2/6). Patients undergoing laparoscopic surgery, however, did have a shorter hospital stay (1.1 days vs 3.5 days, p < 0.001). All liver specimens were considered adequate. There were no complications related to the liver biopsy. Laparoscopic wedge biopsy of the liver is both a feasible and viable alternative to open wedge biopsy.