Literature DB >> 8263011

The effect of phorbol ester treatment on migration of C3H 10T1/2 and BT5C glioma cells: possible application to carcinogenesis.

P Janik1, B Szaniawska, D Kowalczyk, J Miłoszewska.   

Abstract

Treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and the second-stage promoter 12-O-retinoylphorbol 13-acetate induced down-regulation of protein kinase C (PKC) and enhanced the migration of C3H 10T1/2 cells. In the case of BT5C glioma cells the same negative correlation was observed only after treatment with TPA. The negative control 4 alpha-phorbol affected neither PKC activity nor the migratory ability of both cell lines.

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Year:  1994        PMID： 8263011     DOI： 10.1007/bf01202194

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  24 in total

1.  Investigation of the mechanism for enhancement of radiation transformation in vitro by 12-O-tetradecanoylphorbol-13-acetate.

Authors:  A R Kennedy; J B Little
Journal:  Carcinogenesis       Date:  1980       Impact factor: 4.944

2.  Phorbol ester-induced tumor promotion by downregulation of protein kinase C.

Authors:  K A Droms; A M Malkinson
Journal:  Mol Carcinog       Date:  1991       Impact factor: 4.784

3.  Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters.

Authors:  K Chida; H Hashiba; K Sasaki; T Kuroki
Journal:  Cancer Res       Date:  1986-03       Impact factor: 12.701

4.  Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division.

Authors:  C A Reznikoff; J S Bertram; D W Brankow; C Heidelberger
Journal:  Cancer Res       Date:  1973-12       Impact factor: 12.701

5.  Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.

Authors:  A Rodriguez-Pena; E Rozengurt
Journal:  Biochem Biophys Res Commun       Date:  1984-05-16       Impact factor: 3.575

6.  Soluble phorbol ester binding sites and phospholipid- and calcium-dependent protein kinase activity in cytosol of chick oviduct.

Authors:  M Gschwendt; F Horn; W Kittstein; G Fürstenberger; F Marks
Journal:  FEBS Lett       Date:  1983-10-03       Impact factor: 4.124

7.  Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane.

Authors:  A S Kraft; W B Anderson
Journal:  Nature       Date:  1983 Feb 17-23       Impact factor: 49.962

8.  Special type of morphological reorganization induced by phorbol ester: reversible partition of cell into motile and stable domains.

Authors:  V B Dugina; T M Svitkina; J M Vasiliev; I M Gelfand
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

9.  Growth arrest and polyploidization induced by metahalone microtubule inhibitors on rat glioma cells in culture.

Authors:  B Szaniawska; R Bjerkvig; O D Laerum; K Undheim
Journal:  Anticancer Res       Date:  1986 Jan-Feb       Impact factor: 2.480

10.  Regulation of motility in bovine brain endothelial cells.

Authors:  E M Rosen; S Jaken; W Carley; P M Luckett; E Setter; M Bhargava; I D Goldberg
Journal:  J Cell Physiol       Date:  1991-02       Impact factor: 6.384
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  1 in total

1.  Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10.

Authors:  N Sagawa; H Fujita; Y Banno; Y Nozawa; H Katoh; N Kuzumaki
Journal:  Br J Cancer       Date:  2003-02-24       Impact factor: 7.640
  1 in total

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