Literature DB >> 8262868

Effect of hydroxypropyl-beta-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis.

J S Hostetler1, L H Hanson, D A Stevens.   

Abstract

The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl beta-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses > or = 30 mg/kg/day solubilized in hydroxypropyl-beta-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.

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Year:  1993        PMID： 8262868     DOI： 10.1093/jac/32.3.459

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  8 in total

1.  Efficacy of micafungin alone or in combination against systemic murine aspergillosis.

Authors:  Javier Capilla Luque; Karl V Clemons; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

2.  Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs.

Authors:  Karl V Clemons; Gloria M Gonzalez; Gaurav Singh; Jackie Imai; Marife Espiritu; Rachana Parmar; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

3.  Enhanced bioavailability of itraconazole in hydroxypropyl-beta-cyclodextrin solution versus capsules in healthy volunteers.

Authors:  J A Barone; B L Moskovitz; J Guarnieri; A E Hassell; J L Colaizzi; R H Bierman; L Jessen
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

4.  Efficacy of nikkomycin Z against experimental pulmonary blastomycosis.

Authors:  K V Clemons; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

5.  Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis.

Authors:  Perparim Kamberi; Raymond A Sobel; Karl V Clemons; Andreas Waldvogel; Joan M Striebel; Paul L Williams; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2006-12-18       Impact factor: 5.191

6.  Activities of the triazole SCH 51048 against Coccidioides immitis in vitro and in vivo.

Authors:  K V Clemons; M E Homola; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1995-05       Impact factor: 5.191

7.  Efficacy of recombinant gamma interferon for treatment of systemic cryptococcosis in SCID mice.

Authors:  K V Clemons; J E Lutz; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

8.  Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.

Authors:  K V Clemons; M Martinez; L Calderon; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191
  8 in total

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