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Literature DB >> 8262519

Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.

M F Rousseau-Merck¹, J Hillion, P Jonveaux, P Couillin, P Seité, H J Thiesen, R Berger.

Abstract

Nine KOX zinc finger genes were localized on four human chromosomes by in situ hybridization of cDNA probes to metaphase chromosomes. KOX1 (ZNF10), KOX11 (ZNF18), and KOX12 (ZNF19) were mapped to chromosome bands 12q24.33, 17p13-p12, and 16q22-q23, respectively. Six other KOX genes were localized on chromosome 19: KOX6 (ZNF14) and KOX13 (ZNF20) to 19p13.3-p13.2, KOX5 (ZNF13) and KOX22 (ZNF27) to 19q13.2-qter, and KOX24 (ZNF28) and KOX28 (ZNF30) to 19q13.4. Pulsed field gel electrophoresis experiments showed that the pairs of KOX genes found on the chromosome bands 12q24.33, 16q22-q23, 19p13.3-p13.2, or 19q13.3-qter lie within 200-300 kb DNA fragments. This suggests the existence of KOX gene clusters on these chromosomal bands.

Entities: Gene Species

Mesh：

Substances：

Year: 1993 PMID： 8262519 DOI： 10.1007/bf00420943

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

25 in total

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7. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10.

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8. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively.

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Journal: Hum Genet Date: 1991-04 Impact factor: 4.132

9. Isolation and expression of linked zinc finger gene clusters on human chromosome 11q.

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10. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

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3 in total