Literature DB >> 8262049

Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.

G M Wulf1, C N Adra, B Lim.   

Abstract

The vav proto-oncogene is universally and specifically expressed in hematopoietic cells. vav contains a unique array of motifs allowing the protein to function as a signal transducer and possibly as a transcription factor. Under certain in vitro culture conditions murine embryonic stem cells develop into colonies containing multiple hematopoietic lineages. In embryonic stem cell lines, constitutively expressing high levels of antisense vav transcripts through a stably integrated transgene, differentiation into hematopoietic cells is disrupted. This observation presents the first evidence that vav has a critical role in the development of hematopoietic cells from totipotent cells.

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Year:  1993        PMID： 8262049      PMCID： PMC413767          DOI： 10.1002/j.1460-2075.1993.tb06200.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  34 in total

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Authors:  A J Ridley; H F Paterson; C L Johnston; D Diekmann; A Hall
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2.  A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations.

Authors:  W Matthews; C T Jordan; G W Wiegand; D Pardoll; I R Lemischka
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

3.  Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors.

Authors:  E Spooncer; C M Heyworth; A Dunn; T M Dexter
Journal:  Differentiation       Date:  1986       Impact factor: 3.880

4.  The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.

Authors:  M J Klemsz; S R McKercher; A Celada; C Van Beveren; R A Maki
Journal:  Cell       Date:  1990-04-06       Impact factor: 41.582

5.  Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

Authors:  N Li; A Batzer; R Daly; V Yajnik; E Skolnik; P Chardin; D Bar-Sagi; B Margolis; J Schlessinger
Journal:  Nature       Date:  1993-05-06       Impact factor: 49.962

6.  Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.

Authors:  N W Gale; S Kaplan; E J Lowenstein; J Schlessinger; D Bar-Sagi
Journal:  Nature       Date:  1993-05-06       Impact factor: 49.962

7.  Mechanism of activation of the vav protooncogene.

Authors:  J Coppola; S Bryant; T Koda; D Conway; M Barbacid
Journal:  Cell Growth Differ       Date:  1991-02

8.  High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.

Authors:  B Millauer; S Wizigmann-Voos; H Schnürch; R Martinez; N P Møller; W Risau; A Ullrich
Journal:  Cell       Date:  1993-03-26       Impact factor: 41.582

9.  Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.

Authors:  E Gulbins; K M Coggeshall; G Baier; S Katzav; P Burn; A Altman
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

10.  Hematopoietic commitment during embryonic stem cell differentiation in culture.

Authors:  G Keller; M Kennedy; T Papayannopoulou; M V Wiles
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272
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  12 in total

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Authors:  M T Voso; T C Burn; G Wulf; B Lim; G Leone; D G Tenen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

2.  A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.

Authors:  C K Qu; Z Q Shi; R Shen; F Y Tsai; S H Orkin; G S Feng
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

3.  Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.

Authors:  W Mahana; T M Zhao; R Teller; M A Robinson; T J Kindt
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

4.  Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells.

Authors:  M Levinson-Dushnik; N Benvenisty
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

5.  The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity.

Authors:  I Ben-Porath; O Yanuka; N Benvenisty
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

6.  Hematopoietic development of vav-/- mouse embryonic stem cells.

Authors:  R Zhang; F Y Tsai; S H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

7.  Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

Authors:  Z S Ye; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

8.  Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

Authors:  L Robb; I Lyons; R Li; L Hartley; F Köntgen; R P Harvey; D Metcalf; C G Begley
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

9.  Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.

Authors:  C N Adra; J M Lelias; H Kobayashi; M Kaghad; P Morrison; J D Rowley; B Lim
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

10.  Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

Authors:  T Matsuguchi; R C Inhorn; N Carlesso; G Xu; B Druker; J D Griffin
Journal:  EMBO J       Date:  1995-01-16       Impact factor: 11.598
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