Literature DB >> 8260280

Cardiac arrest in a young woman with the long QT syndrome and concomitant astemizole ingestion.

P Broadhurst1, A W Nathan.   

Abstract

Ventricular fibrillation developed in a 19 year old woman taking the antihistamine astemizole. She was successfully resuscitated. QTc prolongation was found and persisted despite withdrawal of the drug. Aggravation of congenital long QTc syndrome by astemizole is postulated. More caution should be exercised with the use of this drug.

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Year:  1993        PMID： 8260280      PMCID： PMC1025361          DOI： 10.1136/hrt.70.5.469

Source DB:  PubMed          Journal:  Br Heart J        ISSN： 0007-0769


  5 in total

1.  ECG studies with astemizole.

Authors:  T M Craft; G Vanden Bussche; J De Cree; J V Griffiths
Journal:  Hum Toxicol       Date:  1987-11

2.  Torsades de pointes after terfenadine-itraconazole interaction.

Authors:  S Pohjola-Sintonen; M Viitasalo; L Toivonene; P Neuvonen
Journal:  BMJ       Date:  1993-01-16

3.  Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-receptor antagonists.

Authors:  R Levi; J O Kuye
Journal:  Eur J Pharmacol       Date:  1974-08       Impact factor: 4.432

4.  The long QT syndrome. Prospective longitudinal study of 328 families.

Authors:  A J Moss; P J Schwartz; R S Crampton; D Tzivoni; E H Locati; J MacCluer; W J Hall; L Weitkamp; G M Vincent; A Garson
Journal:  Circulation       Date:  1991-09       Impact factor: 29.690

5.  The long QT syndrome: a prospective international study.

Authors:  A J Moss; P J Schwartz; R S Crampton; E Locati; E Carleen
Journal:  Circulation       Date:  1985-01       Impact factor: 29.690
  5 in total
  7 in total

Review 1.  Blockade of cardiac potassium and other channels by antihistamines.

Authors:  E Delpón; C Valenzuela; J Tamargo
Journal:  Drug Saf       Date:  1999       Impact factor: 5.606

Review 2.  Drug-induced arrhythmia: pharmacogenomic prescribing?

Authors:  Elijah R Behr; Dan Roden
Journal:  Eur Heart J       Date:  2012-10-22       Impact factor: 29.983

Review 3.  Informatics confronts drug-drug interactions.

Authors:  Bethany Percha; Russ B Altman
Journal:  Trends Pharmacol Sci       Date:  2013-02-13       Impact factor: 14.819

Review 4.  Comparative tolerability of second generation antihistamines.

Authors:  F Horak; U P Stübner
Journal:  Drug Saf       Date:  1999-05       Impact factor: 5.606

5.  Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information.

Authors:  Ha Young Jang; Jihyeon Song; Jae Hyun Kim; Howard Lee; In-Wha Kim; Bongki Moon; Jung Mi Oh
Journal:  NPJ Digit Med       Date:  2022-07-11

Review 6.  H1-receptor antagonists. Comparative tolerability and safety.

Authors:  F E Simons
Journal:  Drug Saf       Date:  1994-05       Impact factor: 5.606

Review 7.  Safety of antihistamines in children.

Authors:  A P Ten Eick; J L Blumer; M D Reed
Journal:  Drug Saf       Date:  2001       Impact factor: 5.228
  7 in total

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