A E Mahfouz1, B Hamm, K J Wolf. 1. Department of Radiology, Klinikum Steglitz, Freie Universität Berlin, Germany.
Abstract
PURPOSE: To assess the value of peripheral washout of contrast medium in differentiating benign from malignant focal liver lesions. MATERIALS AND METHODS: One hundred two patients, 49 with malignant liver tumors and 53 with benign lesions, underwent unenhanced T1- and T2-weighted and dynamic gadolinium-enhanced magnetic resonance (MR) imaging. Dynamic contrast material-enhanced MR imaging was performed before and up to 10 minutes after intravenous administration of a bolus of gadopentetate dimeglumine (0.1 mmol/kg). RESULTS: On the dynamic contrast-enhanced images, 12 of the 49 malignant tumors had a rim that was hypo-intense to the center of the lesion ("peripheral washout" sign); this rim was best seen 10 minutes after administration of contrast material. This sign was absent in the remaining 37 malignant tumors as well as in all 53 benign lesions (P < .001). The peripheral washout sign had a sensitivity of 24.5% and a specificity of 100% in the diagnosis of malignancies of the liver. The malignant tumors with peripheral washout showed no difference in signal intensity between the periphery and the center on the unenhanced T1- and T2-weighted images. CONCLUSION: Peripheral washout is a specific sign of malignancy in dynamic gadolinium-enhanced MR imaging of liver lesions.
PURPOSE: To assess the value of peripheral washout of contrast medium in differentiating benign from malignant focal liver lesions. MATERIALS AND METHODS: One hundred two patients, 49 with malignant liver tumors and 53 with benign lesions, underwent unenhanced T1- and T2-weighted and dynamic gadolinium-enhanced magnetic resonance (MR) imaging. Dynamic contrast material-enhanced MR imaging was performed before and up to 10 minutes after intravenous administration of a bolus of gadopentetate dimeglumine (0.1 mmol/kg). RESULTS: On the dynamic contrast-enhanced images, 12 of the 49 malignant tumors had a rim that was hypo-intense to the center of the lesion ("peripheral washout" sign); this rim was best seen 10 minutes after administration of contrast material. This sign was absent in the remaining 37 malignant tumors as well as in all 53 benign lesions (P < .001). The peripheral washout sign had a sensitivity of 24.5% and a specificity of 100% in the diagnosis of malignancies of the liver. The malignant tumors with peripheral washout showed no difference in signal intensity between the periphery and the center on the unenhanced T1- and T2-weighted images. CONCLUSION: Peripheral washout is a specific sign of malignancy in dynamic gadolinium-enhanced MR imaging of liver lesions.
Authors: Joon Seok Lim; Myeong-Jin Kim; Kang Young Lee; Nam Kyu Kim; Jin-Sub Choi; Joo Hee Kim; Young Taik Oh; Won Ho Kim; Ki Whang Kim Journal: Korean J Radiol Date: 2004 Oct-Dec Impact factor: 3.500
Authors: Kheng Song Leow; Christine Ying Kwok; Hsien Min Low; Rahul Lohan; Tze Chwan Lim; Su Chong Albert Low; Cher Heng Tan Journal: Australas J Ultrasound Med Date: 2022-07-04
Authors: Khaled M Elsayes; John R Leyendecker; Christine O Menias; Erica P Oliveira; Vamsidhar R Narra; William C Chapman; Moataz H Hassanien; Mohamed S Elsharkawy; Jeffrey J Brown Journal: HPB (Oxford) Date: 2007 Impact factor: 3.647