Differential incorporation of processes derived from different classes of neurons into senile plaques in Alzheimer's disease.

The incorporation of neurites into amyloid deposits is an important step in the formation of senile plaques in Alzheimer's disease. It is unknown whether all neuronal types contribute neurites equally to plaques, or whether the processes of certain types are preferentially incorporated. We addressed this question by comparing the incorporation into neocortical plaques of neurites containing the widely distributed neuronal markers chromogranin A (CgA), parvalbumin (PV) and calbindin D-28K (CaBP) in relation to the number of neuronal perikarya expressing each of these substances in the neocortex. We found a consistent, statistically significant ranking, so that CgA-immunoreactive (ir) neurites were preferentially incorporated into plaques in comparison with PV-ir, and PV-ir were favoured over CaBP-ir neurites.