| Literature DB >> 2110534 |
R Weiler1, H Lassmann, P Fischer, K Jellinger, H Winkler.
Abstract
Chromogranin A and synaptin/synaptophysin were characterized by immunological methods in human autopsy brain tissue from patients with Alzheimer's and Pick's disease. In immunoblots there was no qualitative difference between the antigens in control and diseased brain, but significant quantitative differences were found. In all Alzheimer cases there was a significantly lower level of synaptin/synaptophysin, whereas chromogranin A was higher in 4 out of 5 cases and in all cases relative to synaptin/synaptophysin. An analogous finding was obtained for Pick's disease. Immunohistologically a consistent staining of neuritic plaques for chromogranin A, but not for secretogranin II was found in Alzheimer cases. In Pick's disease the characteristic Pick bodies showed an analogous specific immunostaining.Entities:
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Year: 1990 PMID： 2110534 DOI： 10.1016/0014-5793(90)81408-g
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124