| Literature DB >> 8255845 |
A J Krentz1, J Pace, W Somerville, P M Clark, M Nattrass.
Abstract
The role of somatostatin analogues in the medical management of insulinomas is unclear. We describe an elderly patient with clinical and biochemical features of endogenous hyperinsulinism attributable to a benign islet B cell disorder whose incapacitating neuroglycopaenic symptoms responded dramatically to octreotide 50 micrograms subcutaneously at 2200 h each night. Octreotide suppressed inappropriate plasma concentrations of insulin thereby preventing fasting hypoglycaemia. Fasting concentrations of proinsulin, and 32-33 split proinsulin, as determined by two-site monoclonal antibody-based immunoradiometric assays, were also suppressed by octreotide.Entities:
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Year: 1993 PMID： 8255845 PMCID： PMC2399757 DOI： 10.1136/pgmj.69.815.735
Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401