K D Lessnau1, S Milanese, W Talavera. 1. Department of Pulmonary/Critical Care Medicine, Cabrini Medical Center, New York 10003.
Abstract
PURPOSE: To evaluate the pathogenicity of Mycobacterium gordonae in patients with and without human immunodeficiency virus (HIV) infection. PATIENTS AND METHODS: Twenty-one HIV-positive and 15 HIV-negative patients in a tertiary care center. A descriptive, case-control, and cohort study with a review of the literature with a computer-based data research. RESULTS: The 15 HIV-negative patients had colonization only. Seven HIV-positive patients had colonization, 12 had possible disease, and 2 had dissemination. The two patients with definitive dissemination improved objectively with treatment. CONCLUSION: Mycobacterium gordonae in HIV-negative patients is rarely a pathogen. In HIV-positive patients with a low CD4+ cell count, it can cause significant disease and treatment is beneficial.
PURPOSE: To evaluate the pathogenicity of Mycobacterium gordonae in patients with and without human immunodeficiency virus (HIV) infection. PATIENTS AND METHODS: Twenty-one HIV-positive and 15 HIV-negative patients in a tertiary care center. A descriptive, case-control, and cohort study with a review of the literature with a computer-based data research. RESULTS: The 15 HIV-negative patients had colonization only. Seven HIV-positivepatients had colonization, 12 had possible disease, and 2 had dissemination. The two patients with definitive dissemination improved objectively with treatment. CONCLUSION:Mycobacterium gordonae in HIV-negative patients is rarely a pathogen. In HIV-positivepatients with a low CD4+ cell count, it can cause significant disease and treatment is beneficial.
Authors: Clare L van Halsema; Violet N Chihota; Nicolaas C Gey van Pittius; Katherine L Fielding; James J Lewis; Paul D van Helden; Gavin J Churchyard; Alison D Grant Journal: Biomed Res Int Date: 2015-05-28 Impact factor: 3.411