Literature DB >> 8249632

Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.

B Zhang1, K Long.   

Abstract

Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and 7.74 mumol.L-1, respectively. Gla A 10 and 100 mumol.L-1 increased the cAMP levels in platelets. In combination with imazodan hydrochloride, Gla A (1-100 mumol.L-1) caused a marked increase of platelet cAMP levels, while no effect with PGE1.

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Year:  1993        PMID： 8249632

Source DB:  PubMed          Journal:  Zhongguo Yao Li Xue Bao        ISSN： 0253-9756


  5 in total

1.  Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC-7721 cells.

Authors:  Lisha Tang; Xiaofeng Jin; Xiaohui Hu; Xiaoding Hu; Zulong Liu; Long Yu
Journal:  Oncol Lett       Date:  2015-12-03       Impact factor: 2.967

Review 2.  Natural Products for Antithrombosis.

Authors:  Cen Chen; Feng-Qing Yang; Qian Zhang; Feng-Qin Wang; Yuan-Jia Hu; Zhi-Ning Xia
Journal:  Evid Based Complement Alternat Med       Date:  2015-05-17       Impact factor: 2.629

3.  Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

Authors:  Wei Li; Xiaorong Tang; Wenxiu Yi; Qiang Li; Lijie Ren; Xiaohui Liu; Chunjun Chu; Yukio Ozaki; Jian Zhang; Li Zhu
Journal:  PLoS One       Date:  2013-12-30       Impact factor: 3.240

Review 4.  Coagulation System Activation for Targeting of COVID-19: Insights into Anticoagulants, Vaccine-Loaded Nanoparticles, and Hypercoagulability in COVID-19 Vaccines.

Authors:  Mohamed S Abdel-Bakky; Elham Amin; Mohamed G Ewees; Nesreen I Mahmoud; Hamdoon A Mohammed; Waleed M Altowayan; Ahmed A H Abdellatif
Journal:  Viruses       Date:  2022-01-24       Impact factor: 5.048

5.  Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway.

Authors:  Chenyang Han; Yi Yang; Yongjia Sheng; Jin Wang; Xiaohong Zhou; Wenyan Li; Li Guo; Caiqun Zhang; Qiao Ye
Journal:  Aging (Albany NY)       Date:  2021-09-27       Impact factor: 5.682
  5 in total

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