Literature DB >> 26893714

Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC-7721 cells.

Lisha Tang1, Xiaofeng Jin1, Xiaohui Hu1, Xiaoding Hu1, Zulong Liu1, Long Yu1.   

Abstract

Liver cancer is one of the most common types of cancer, and hepatoma demonstrates a poor long-term prognosis. The present study reports that glaucocalyxin A (GLA), a natural product isolated from Rabdosia umbrosa, inhibits the growth of the liver cancer Focus and SMMC-7721 cell lines in a dose- and time-dependent manner. The present study revealed that GLA arrested the liver cancer cells at the G2/M stage of the cell cycle and led to decreased expression of caspase 3 and the cleavage of poly(adenosine diphosphate-ribose) polymerase. Overall, the present study demonstrated that GLA inhibits the growth of liver cancer cells by G2/M stage cell-cycle arrest and cell apoptosis.

Entities:  

Keywords:  G2/M arrest; apoptosis; growth inhibition; liver cancer

Year:  2015        PMID： 26893714      PMCID： PMC4733948          DOI： 10.3892/ol.2015.4002

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


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