| Literature DB >> 8249436 |
T M Kündig1, C P Kalberer, H Hengartner, R M Zinkernagel.
Abstract
The effects of immunity to vaccinia virus on the efficiency of vaccination with a vaccinia recombinant virus were studied. In mice the efficiency and duration of the B-cell response to the recombinant gene product of a second vaccinia recombinant virus were suppressed for more than 9 months, i.e. practically lifelong. Antibody titres against the recombinant gene product were not only lower but also lasted for a shorter time. Thus, immunity to vaccinia virus may influence both the titre and duration of the antibody response induced by a second distinct vaccinia recombinant vaccine.Entities:
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Year: 1993 PMID: 8249436 DOI: 10.1016/0264-410x(93)90079-d
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641