Literature DB >> 8242580

Reversal of multidrug resistance to cancer chemotherapy.

B Leyland-Jones1, W Dalton, G A Fisher, B I Sikic.   

Abstract

In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This article reviews the different classes of the current major modulators of multidrug resistance.

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Year:  1993        PMID： 8242580     DOI： 10.1002/1097-0142(19931201)72:11+<3484::aid-cncr2820721615>3.0.co;2-l

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  8 in total

1.  Multidrug resistance increment in a human colon carcinoma cell line by colchicine.

Authors:  M J Ruiz Gómez; L Gil; A Souviron; M Martínez Morillo
Journal:  J Physiol Biochem       Date:  2000-03       Impact factor: 4.158

2.  Verapamil sensitisation to alkaloids on colchicine-selected human colon adenocarcinoma cells.

Authors:  M J Ruiz Gómez; A Souviron; L Gil; M Martínez Morillo
Journal:  J Physiol Biochem       Date:  2001-12       Impact factor: 4.158

3.  P-glycoprotein, glutathione and glutathione S-transferase increase in a colon carcinoma cell line by colchicine.

Authors:  M J Ruiz-Gómez; A Souviron; M Martínez-Morillo; L Gil
Journal:  J Physiol Biochem       Date:  2000-12       Impact factor: 4.158

4.  Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector.

Authors:  Dong Xu; Doug McCarty; Alda Fernandes; Michael Fisher; R J Samulski; R L Juliano
Journal:  Mol Ther       Date:  2005-04       Impact factor: 11.454

5.  Effect of pluronic P85 on ATPase activity of drug efflux transporters.

Authors:  Elena V Batrakova; Shu Li; Yili Li; Valery Yu Alakhov; Alexander V Kabanov
Journal:  Pharm Res       Date:  2004-12       Impact factor: 4.200

6.  Active cell membrane mechanisms involved in the exclusion of Rh 123 allow distinction between normal and tumoral cells.

Authors:  G Lizard; M C Chignol; Y Chardonnet; D Schmitt
Journal:  Cell Biol Toxicol       Date:  1994-12       Impact factor: 6.691

7.  Use of the comet assay for assessment of drug resistance and its modulation in vivo.

Authors:  P Huang; P L Olive; R E Durand
Journal:  Br J Cancer       Date:  1998       Impact factor: 7.640

8.  High-dose cyclosporin with etoposide--toxicity and pharmacokinetic interaction in children with solid tumours.

Authors:  G Bisogno; F Cowie; A Boddy; H D Thomas; G Dick; C R Pinkerton
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640
  8 in total

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